[CAS NO. 791028-27-8] Amino-PEG2-C2-acid
PRODUCTS SPECIFICATIONS [791028-27-8]
DESCRIPTION [791028-27-8]
Overview
| MDL | MFCD20926377 |
|---|---|
| Molecular Weight | 177.20 |
| Molecular Formula | C7H15NO4 |
| SMILES | O=C(O)CCOCCOCCN |
Summary
Amino-PEG2-C2-acid is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Amino-PEG2-C2-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1] .
IC50 & Target
|
Cleavable |
PEGs |
In Vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
