[CAS NO. 796073-68-2] DM4-SMe

Name: DM4-SMe
Brand: Arctom Scientific
SKU: HY-130082

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PRODUCTS SPECIFICATIONS [796073-68-2]

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Catalog

HY-130082

Brand

MCE

CAS

796073-68-2

DESCRIPTION [796073-68-2]

Overview

MDL	MFCD28400104
Molecular Weight	826.46
Molecular Formula	C39H56ClN3O10S2
SMILES	C[C@]12[C@H]([C@@H]([C@](O3)([H])C[C@]([C@](/C=C/C=C(C)/CC4=CC(N(C)C(C[C@]2([H])OC([C@H](C)N(C)C(CCC(C)(C)SSC)=O)=O)=O)=C(C(OC)=C4)Cl)([H])OC)(NC3=O)O)C)O1

For research use only. We do not sell to patients.

Summary

DM4-SMe is a metabolite of antibody-maytansin conjugates (AMCs) and a tubulin inhibitor, and also a cytotoxic moiety of antibody-drug conjugates (ADCs) , which can be linked to antibody through disulfide bond or stable thioether bond. DM4-SMe inhibits KB cells with an IC ₅₀ of 0.026 nM ^[1] ^[2] .

IC50 & Target

Maytansinoids

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 121.00 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2100 mL	6.0499 mL	12.0998 mL
5 mM	0.2420 mL	1.2100 mL	2.4200 mL
10 mM	0.1210 mL	0.6050 mL	1.2100 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (3.02 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (3.02 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (3.02 mM); Clear solution

* All of the co-solvents are available by MCE.