[CAS NO. 80474-14-2] Fluticasone(propionate)
PRODUCTS SPECIFICATIONS [80474-14-2]
DESCRIPTION [80474-14-2]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 500.57 |
| Molecular Formula | C25H31F3O5S |
| SMILES | O=C(CC)O[C@@]([C@]([C@@]1([H])C2)(C[C@H](O)[C@](F)([C@]3(C=C4)C)[C@@]1([H])C[C@H](F)C3=CC4=O)C)([C@@H]2C)C(SCF)=O |
1 Publications Citing Use of MCE
Summary
Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity ( K D ) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity [1] [2] .
In Vitro
Fluticasone propionate inhibits TNFα-induced E-selectin expression, with an IC 50 of 1 nM [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 199.77 mM ; Need ultrasonic)
H 2 O : 1 mg/mL ( 2.00 mM ; ultrasonic and warming and heat to 80°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.9977 mL | 9.9886 mL | 19.9772 mL |
| 5 mM | 0.3995 mL | 1.9977 mL | 3.9954 mL |
| 10 mM | 0.1998 mL | 0.9989 mL | 1.9977 mL |
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1.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (4.99 mM); Clear solution
References
- [1] Bryson HM, et al. Intranasal fluticasone propionate. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in allergic rhinitis. Drugs. 1992;43(5):760-775.
- [2] Johnson M. The anti-inflammatory profile of fluticasone propionate. Allergy. 1995;50(23 Suppl):11-14.
- [3] Singanayagam A, et al. Effect of fluticasone propionate on virus-induced airways inflammation and anti-viral immune responses in mice. Lancet. 2015 Feb 26;385 Suppl 1:S88.
Synonyms
