[CAS NO. 843666-40-0] Boc-C16-COOH
PRODUCTS SPECIFICATIONS [843666-40-0]
DESCRIPTION [843666-40-0]
Overview
| MDL | MFCD09991735 |
|---|---|
| Molecular Weight | 370.57 |
| Molecular Formula | C22H42O4 |
| SMILES | CC(C)(OC(CCCCCCCCCCCCCCCCC(O)=O)=O)C |
Summary
Boc-C16-COOH is a non-cleavable ADC linker used in the synthesis of
antibody-drug conjugates (ADCs)
. Boc-C16-COOH is also a alkyl chain-based
PROTAC
linker that can be used in the synthesis of
PROTACs
[1]
IC50 & Target
|
Non-cleavable |
In Vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker
[1]
.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 269.85 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.6985 mL | 13.4927 mL | 26.9855 mL |
| 5 mM | 0.5397 mL | 2.6985 mL | 5.3971 mL |
| 10 mM | 0.2699 mL | 1.3493 mL | 2.6985 mL |
References
