[CAS NO. 84692-91-1] Arglabin
PRODUCTS SPECIFICATIONS [84692-91-1]
DESCRIPTION [84692-91-1]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 246.30 |
| Molecular Formula | C15H18O3 |
| SMILES | C[C@]1(CC[C@](C2=C)([H])[C@@](OC2=O)([H])[C@@]3([H])C(C)=CC4)[C@]34O1 |
Summary
Arglabin ((+)-Arglabin), a natural product isolated from Artemisia glabella , is a NLRP3 inflammasome inhibitor. Arglabin shows anti-inflammatory and antitumor activities [1] . The antitumor activity of Arglabin proceeds through its inhibition of farnesyl transferase which leads to the activation of RAS proto-oncogene [2] .
IC50 & Target
|
NLRP3 |
In Vitro
The antitumor activity of arglabin proceeds through its inhibition of farnesyl transferase which leads to the activation of RAS proto-oncogene, a process that is believed to play a pivotal role in 20-30% of all human tumors. It actually inhibits the incorporation of farnesyl pyrophosphate into human H-ras proteins by the enzyme farnesyl transferase (FTase) [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Arglabin reduces inflammation and plasma lipids, increases autophagy, and orients tissue macrophages into an anti-inflammatory phenotype in ApoE2.Ki mice fed a high-fat diet [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 100 mg/mL ( 406.01 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.0601 mL | 20.3004 mL | 40.6009 mL |
| 5 mM | 0.8120 mL | 4.0601 mL | 8.1202 mL |
| 10 mM | 0.4060 mL | 2.0300 mL | 4.0601 mL |
References
Synonyms
