[CAS NO. 854601-60-8] m-PEG11-Amine
PRODUCTS SPECIFICATIONS [854601-60-8]
DESCRIPTION [854601-60-8]
Overview
| MDL | MFCD27977521 |
|---|---|
| Molecular Weight | 515.64 |
| Molecular Formula | C23H49NO11 |
| SMILES | COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN |
Summary
m-PEG11-Amino is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . m-PEG11-Amine is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1] .
IC50 & Target
|
Cleavable |
PEGs |
In Vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid-liquid mixture
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
