[CAS NO. 863971-12-4] MMAF-OMe
PRODUCTS SPECIFICATIONS [863971-12-4]
DESCRIPTION [863971-12-4]
Overview
| MDL | MFCD30535529 |
|---|---|
| Molecular Weight | 745.99 |
| Molecular Formula | C40H67N5O8 |
| SMILES | CC[C@H](C)[C@@H]([C@@H](CC(N1[C@@H](CCC1)[C@@H]([C@@H](C)C(N[C@H](C(OC)=O)CC2=CC=CC=C2)=O)OC)=O)OC)N(C([C@H](C(C)C)NC([C@H](C(C)C)NC)=O)=O)C |
1 Publications Citing Use of MCE
Summary
MMAF-Ome, an antitubulin agent, is also an ADC cytotoxin . MMAF-Ome inhibits several tumor cell lines with IC 50 s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4 - ) cell lines, respectively.
IC50 & Target
|
Auristatin |
In Vitro
2.5F-Fc and 2.5F-Fc-MMAF have similar IC 50 values (6.9±1.1 vs. 8.3±1.3 nM, respectively), indicating that MMAF conjugation has negligible impact on integrin-binding affinity [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years |
* The compound is unstable in solutions, freshly prepared is recommended.
Solvent & Solubility
DMSO : ≥ 100 mg/mL ( 134.05 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.3405 mL | 6.7025 mL | 13.4050 mL |
| 5 mM | 0.2681 mL | 1.3405 mL | 2.6810 mL |
| 10 mM | 0.1341 mL | 0.6703 mL | 1.3405 mL |
