[CAS NO. 863971-19-1] McMMAF
PRODUCTS SPECIFICATIONS [863971-19-1]
DESCRIPTION [863971-19-1]
Overview
| MDL | MFCD25976741 |
|---|---|
| Molecular Weight | 925.16 |
| Molecular Formula | C49H76N6O11 |
| SMILES | O=C([C@H](C)[C@H]([C@]1([H])CCCN1C(C[C@@H](OC)[C@@]([H])(N(C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(CCCCCN2C(C=CC2=O)=O)=O)=O)=O)C)[C@@H](C)CC)=O)OC)N[C@H](C(O)=O)CC3=CC=CC=C3 |
4 Publications Citing Use of MCE
Summary
McMMAF is a protective group (maleimidocaproyl)-conjugated MMAF, which is a potent tubulin polymerization inhibitor. McMMAF can be used as a drug-linker for antibody-drug conjugates (ADC) . McMMAF ADCs are uncleavable, and must be internalized and degraded within a cell, releasing cysteine-McMMAF as the active drug [1] [2] .
IC50 & Target
|
Auristatin |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
-20°C, stored under nitrogen
* The compound is unstable in solutions, freshly prepared is recommended.
Solvent & Solubility
DMSO : ≥ 100 mg/mL ( 108.09 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.0809 mL | 5.4045 mL | 10.8089 mL |
| 5 mM | 0.2162 mL | 1.0809 mL | 2.1618 mL |
| 10 mM | 0.1081 mL | 0.5404 mL | 1.0809 mL |
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1.
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2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 5 mg/mL (5.40 mM); Clear solution
-
3.
Add each solvent one by one: 1% DMSO >> 99% saline
Solubility: ≥ 0.5 mg/mL (0.54 mM); Clear solution
References
