[CAS NO. 863971-24-8] Mc-MMAE
PRODUCTS SPECIFICATIONS [863971-24-8]
DESCRIPTION [863971-24-8]
Overview
| MDL | MFCD28167757 |
|---|---|
| Molecular Weight | 911.18 |
| Molecular Formula | C49H78N6O10 |
| SMILES | O=C1N(CCCCCC(N(C)[C@H](C(N[C@@H](C(C)C)C(N([C@@H]([C@@H](C)CC)[C@@H](CC(N2[C@H]([C@H](OC)[C@H](C(N[C@@H]([C@H](C3=CC=CC=C3)O)C)=O)C)CCC2)=O)OC)C)=O)=O)C(C)C)=O)C(C=C1)=O |
Summary
Mc-MMAE is a protective group (maleimidocaproyl)-conjugated monomethyl auristatin E (MMAE), which is a potent tubulin inhibitor. Mc-MMAE is a drug-linker conjugate for ADC.
IC50 & Target
|
Auristatin |
In Vitro
Synthesis of maleimidocaproyl-MMAE (mc-MMAE) requires the addition of maleimidocaproic acid to a solution of MMAE in dichloromethane followed by the addition of diethyl cyanophosphonate and diisopropylethylamine [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, stored under nitrogen
* The compound is unstable in solutions, freshly prepared is recommended.
Solvent & Solubility
DMSO : 180 mg/mL ( 197.55 mM ; Need ultrasonic)
H 2 O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.0975 mL | 5.4874 mL | 10.9748 mL |
| 5 mM | 0.2195 mL | 1.0975 mL | 2.1950 mL |
| 10 mM | 0.1097 mL | 0.5487 mL | 1.0975 mL |
