[CAS NO. 870487-10-8] Boc-Val-Cit-PAB-PNP
PRODUCTS SPECIFICATIONS [870487-10-8]
DESCRIPTION [870487-10-8]
Overview
| MDL | MFCD22417105 |
|---|---|
| Molecular Weight | 644.67 |
| Molecular Formula | C30H40N6O10 |
| SMILES | O=C(OC1=CC=C(C=C1)[N+]([O-])=O)OCC(C=C2)=CC=C2NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(OC(C)(C)C)=O)=O)=O |
Summary
Boc-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1] .
IC50 & Target
|
Protease Cleavable |
Cleavable |
In Vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
-20°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL ( 155.12 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.5512 mL | 7.7559 mL | 15.5118 mL |
| 5 mM | 0.3102 mL | 1.5512 mL | 3.1024 mL |
| 10 mM | 0.1551 mL | 0.7756 mL | 1.5512 mL |
