[CAS NO. 915365-57-0] Cotinhibitor-1

Name: Cotinhibitor-1
Brand: Arctom Scientific
SKU: HY-32015

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PRODUCTS SPECIFICATIONS [915365-57-0]

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Catalog

HY-32015

Brand

MCE

CAS

915365-57-0

DESCRIPTION [915365-57-0]

Overview

MDL	MFCD13184699
Molecular Weight	553.46
Molecular Formula	C27H27Cl2FN8
SMILES	N#CC1=C(C2=CC(NCC3=CN(CCN4CCCCCC4)N=N3)=CC(Cl)=C2N=C1)NC5=CC=C(F)C(Cl)=C5

For research use only. We do not sell to patients.

2 Publications Citing Use of MCE

Summary

Cot inhibitor-1 (compound 28) is a selective tumor progression loci-2 (Tpl2) kinase inhibitor with an IC ₅₀ of 28 nM. Cot inhibitor-1 shows an inhibition of TNF-alpha production in human whole blood with an IC ₅₀ of 5.7 nM ^[1] .

IC50 & Target

IC50: 28 nM (Tpl2 kinase) ^[1]

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL ( 45.17 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8068 mL	9.0341 mL	18.0682 mL
5 mM	0.3614 mL	1.8068 mL	3.6136 mL
10 mM	0.1807 mL	0.9034 mL	1.8068 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (4.52 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Junjun Wu, et al. Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-alpha production in human whole blood. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3485-8.