[CAS NO. 944561-44-8] Propargyl-PEG2-amine
PRODUCTS SPECIFICATIONS [944561-44-8]
DESCRIPTION [944561-44-8]
Overview
| MDL | MFCD19160595 |
|---|---|
| Molecular Weight | 143.18 |
| Molecular Formula | C7H13NO2 |
| SMILES | NCCOCCOCC#C |
Summary
Propargyl-PEG2-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Propargyl-PEG2-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs [1] [2] .
IC50 & Target
|
Non-cleavable |
PEGs |
In Vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Liquid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 100 mg/mL ( 698.42 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 6.9842 mL | 34.9211 mL | 69.8422 mL |
| 5 mM | 1.3968 mL | 6.9842 mL | 13.9684 mL |
| 10 mM | 0.6984 mL | 3.4921 mL | 6.9842 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (17.46 mM); Clear solution
References
Synonyms
