[CAS NO. 205304-86-5] Tubulysin A
PRODUCTS SPECIFICATIONS [205304-86-5]
DESCRIPTION [205304-86-5]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 844.07 |
| Molecular Formula | C43H65N5O10S |
| SMILES | O=C([C@@]([C@@H](C)CC)([H])NC([C@@H](CCCC1)N1C)=O)N(COC(CC(C)C)=O)[C@@H](C(C)C)C[C@H](C2=NC(C(N[C@H](C[C@H](C)C(O)=O)CC3=CC=C(O)C=C3)=O)=CS2)OC(C)=O |
1 Publications Citing Use of MCE
Summary
Tubulysin A (TubA) is an antibiotic and highly cytotoxic anti-microtubule toxin ( anti-microtubule toxins ) isolated from myxobacteria. Tubulysins are a family of cytotoxic peptides consisting of 9 members (A-I). Tubulysin A has anti-angiogenic, anti-microtubule, anti-mitotic, and anti-proliferative activities. Tubulysin A is also an inducer of apoptosis ( apoptosis ), arresting cells in the G2/M phase, effectively inhibiting tubulin polymerization, and inducing depolymerization of detached microtubules. Tubulysin A is potent cytostatic against multiple tumor cell lines with IC50 in the pmol range. Tubulysin A acts as an ADC cytotoxin ( ADC Cytotoxin ) to synthesize ADC [1] [2] [3] .
IC50 & Target
|
Traditional Cytotoxic Agents |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 100 mg/mL ( 118.47 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.1847 mL | 5.9237 mL | 11.8474 mL |
| 5 mM | 0.2369 mL | 1.1847 mL | 2.3695 mL |
| 10 mM | 0.1185 mL | 0.5924 mL | 1.1847 mL |
-
1.
-
2.
-
3.
References
- [1] Kaur G, et al. Biological evaluation of tubulysin A: a potential anticancer and antiangiogenic natural product. Biochem J. 2006 Jun 1;396(2):235-42.
- [2] Sasse F, et al. Tubulysins, new cytostatic peptides from myxobacteria acting on microtubuli. Production, isolation, physico-chemical and biological properties. J Antibiot (Tokyo). 2000 Sep;53(9):879-85.
- [3] Khalil MW, et al. Mechanism of action of tubulysin, an antimitotic peptide from myxobacteria. Chembiochem. 2006 Apr;7(4):678-83.
