G3-C12 TFA
PRODUCTS SPECIFICATIONS
DESCRIPTION
Overview
| MDL | - |
|---|---|
| Molecular Weight | 1873.00 |
| Molecular Formula | C74H115N23O23S2.C2HF3O2 |
| SMILES | - |
Summary
G3-C12 (TFA) is a galectin-3 binding peptide, with K d of 88 nM, and shows anticancer activity.
IC50 & Target
Kd: 88 nM (Galectin-3) [1] .
In Vitro
G3-C12 (TFA) is a galectin-3 binding peptide, with high affinity (K d ) of 88 nM, but shows no affinity for other galectin family members or to other lectins. G3-C12 (TFA) bearing opolymers N-(2-hydroxypropyl)methacrylamide (HPMA) potently and selectively targets colorectal cancer (CRC) tumour cells over-expressing galectin-3 and displays superior targetability to galectin-3 compared to the galactose bearing copolymer [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Sealed storage, away from moisture
| Powder | -80°C | 2 years |
|---|---|---|
| -20°C | 1 year |
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H 2 O : ≥ 50 mg/mL ( 26.70 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 0.5339 mL | 2.6695 mL | 5.3390 mL |
| 5 mM | 0.1068 mL | 0.5339 mL | 1.0678 mL |
| 10 mM | 0.0534 mL | 0.2670 mL | 0.5339 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 12.5 mg/mL (6.67 mM); Clear solution; Need ultrasonic
