[CAS NO. 1424635-83-5]  TRULI

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PRODUCTS SPECIFICATIONS [1424635-83-5]

Store
Catalog
SLK-E1061
Brand
Selleck
CAS
1424635-83-5

DESCRIPTION [1424635-83-5]

Overview

MDL-
Molecular Weight334.40
Molecular FormulaC18H14N4OS
SMILESO=C(C1=CNC2=NC=CC=C21)/N=C3SC=CN\3CC4=CC=CC=C4

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

TRULI inhibits both with a IC50 of 0.2 nM, suppresses Yap phosphorylation, induces cell proliferation in several cell lines and tissues, and promotes the initial stages of proliferative regeneration of the sensory receptors in the inner ear.

Targets

Lats2 [1]
(in the Vitro kinase assay)
Lats1 [1]
(in vitro kinase assay)
Lats2 [1]
(in vitro kinase assay)
0.2 nM0.2 nM0.2 nM

In vitro

TRULI acts as an inhibitor of Lats kinases in vitro, suppresses Yap phosphorylation, induces cell proliferation in several cell lines and tissues, and promotes the initial stages of proliferative regeneration of the sensory receptors in the inner ear.