[CAS NO. 2249435-90-1] SN-011 (GUN35901)
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PRODUCTS SPECIFICATIONS [2249435-90-1]
Store
Catalog
SLK-E1066
Brand
Selleck
CAS
2249435-90-1
DESCRIPTION [2249435-90-1]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 462.49 |
| Molecular Formula | C25H19FN2O4S |
| SMILES | O=C(C1=CC=C(C2=CC=CC=C2)C=C1)NC3=CC=C(O)C(NS(=O)(C4=CC=C(F)C=C4)=O)=C3 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1622 mL | 10.8110 mL | 21.6221 mL |
| 5 mM | 0.4324 mL | 2.1622 mL | 4.3244 mL |
| 10 mM | 0.2162 mL | 1.0811 mL | 2.1622 mL |
| 50 mM | 0.0432 mL | 0.2162 mL | 0.4324 mL |
Description
SN-011 (GUN35901) is a -specific antagonist with IC50 of 76 nM.
Targets
| STING [1] |
| 76 nM |
In vitro
SN-011 substantially suppresses 2′3′-cGAMP-induced STING oligomerization and phosphorylation assessed by immunoblot in HFFs. SN-011 specifically inhibits STING activation and STING-dependent signaling.
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