[CAS NO. 1513857-77-6] Pemigatinib (INCB054828)

Name: Pemigatinib (INCB054828)
Brand: Arctom Scientific
SKU: SLK-S0088

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PRODUCTS SPECIFICATIONS [1513857-77-6]

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Catalog

SLK-S0088

Brand

Selleck

CAS

1513857-77-6

DESCRIPTION [1513857-77-6]

Overview

MDL	MFCD31706227
Molecular Weight	487.50
Molecular Formula	C24H27F2N5O4
SMILES	FC1=C(C(F)=C(OC)C=C1OC)N(CC2=CNC3=NC(CN4CCOCC4)=CC3=C25)C(N5CC)=O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.0513 mL	10.2564 mL	20.5128 mL
5 mM	0.4103 mL	2.0513 mL	4.1026 mL
10 mM	0.2051 mL	1.0256 mL	2.0513 mL
50 mM	0.0410 mL	0.2051 mL	0.4103 mL

Description

Pemigatinib (INCB054828, Pemazyre) is an orally active and selective inhibitor of with IC50 of 0.4 nM, 0.5 nM, 1.2 nM and 30 nM for FGFR1, FGFR2, FGFR3 and FGFR4, respectively. Pemigatinib has the potential for cholangiocarcinoma.

Targets

FGFR1 ^[1] (Cell-free assay)	FGFR2 ^[1] (Cell-free assay)	FGFR3 ^[1] (Cell-free assay)	FGFR4 ^[1] (Cell-free assay)
0.4 nM	0.5 nM	1.2 nM	30 nM

In vitro

Pemigatinib successfully diminishes the capacity of reactive astrocytes to recruit myeloid cells. Potentially FGFR modulation by pemigatinib may be promising for suppression of proinflammatory astrocyte responses while, at the same time, promoting protective mechanisms in murine and human systems.

References

[1] Robert Roskoski Jr. Pharmacol Res. 2020 Jan;151:104567.
[2] Linnerbauer M, et al. JCI Insight. 2022 Apr 8;7(7):e154824.