[CAS NO. 2249801-12-3] MD2-TLR4-IN-1

Name: MD2-TLR4-IN-1
Brand: Arctom Scientific
SKU: SLK-S0139

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PRODUCTS SPECIFICATIONS [2249801-12-3]

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Catalog

SLK-S0139

Brand

Selleck

CAS

2249801-12-3

DESCRIPTION [2249801-12-3]

Overview

MDL	MFCD32067977
Molecular Weight	421.28
Molecular Formula	C22H14Cl2N4O
SMILES	ClC1=C(C(Cl)=CC=C1)C(NC2=CC=C3NN=C(C3=C2)C4=CC=C5NC=CC5=C4)=O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.3737 mL	11.8686 mL	23.7372 mL
5 mM	0.4747 mL	2.3737 mL	4.7474 mL
10 mM	0.2374 mL	1.1869 mL	2.3737 mL
50 mM	0.0475 mL	0.2374 mL	0.4747 mL

Description

MD2-TLR4-IN-1 (Compound 22m) is a potent inhibitor of . MD2-TLR4-IN-1 (compound 22m) inhibits lipopolysaccharide (LPS)-induced expression of and in macrophages with IC50 of 0.89 μM and 0.53 μM, respectively.

Targets

TLR4 ^[1]	IL-6 ^[1] (Cell-free assay)	TNF-α ^[1] (Cell-free assay)
	0.53 μM	0.89 μM

References

[1] Zhiguo Liu, et al. J Med Chem. 2019 Jun 13;62(11):5453-5469.