[CAS NO. 381168-77-0] ML367
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PRODUCTS SPECIFICATIONS [381168-77-0]
Store
Catalog
SLK-S0161
Brand
Selleck
CAS
381168-77-0
DESCRIPTION [381168-77-0]
Overview
| MDL | MFCD01897460 |
|---|---|
| Molecular Weight | 334.32 |
| Molecular Formula | C19H12F2N4 |
| SMILES | FC1=C(F)C=CC(NC2=NC(C3=CC=NC=C3)=NC4=C2C=CC=C4)=C1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.9911 mL | 14.9557 mL | 29.9115 mL |
| 5 mM | 0.5982 mL | 2.9911 mL | 5.9823 mL |
| 10 mM | 0.2991 mL | 1.4956 mL | 2.9911 mL |
| 50 mM | 0.0598 mL | 0.2991 mL | 0.5982 mL |
Description
ML367 is a potent, micromolar inhibitor of stabilization. ML367 blocks pathways and general responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation.
Targets
| ATAD5 [1] |
In vitro
ML367 is a probe molecule found to block general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation. In this regard, the probe molecule could block DNA repair pathways that function upstream of ATAD5. Additionally, ML367 sensitizes cells possessing a knock-out mutation of the PARP1 gene and as a result may serve as a sensitizer to kill cancer cells defective in the poly (ADP-ribose) polymerase 1 (PARP1)-dependent DNA repair pathway.
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