[CAS NO. 1572510-42-9] JNJ-632
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PRODUCTS SPECIFICATIONS [1572510-42-9]
Store
Catalog
SLK-S0796
Brand
Selleck
CAS
1572510-42-9
DESCRIPTION [1572510-42-9]
Overview
| MDL | MFCD31692402 |
|---|---|
| Molecular Weight | 378.42 |
| Molecular Formula | C18H19FN2O4S |
| SMILES | O=C(NC1=CC(C)=C(F)C=C1)C2=CC=CC(S(=O)(N[C@@H]3COCC3)=O)=C2 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.6426 mL | 13.2128 mL | 26.4257 mL |
| 5 mM | 0.5285 mL | 2.6426 mL | 5.2851 mL |
| 10 mM | 0.2643 mL | 1.3213 mL | 2.6426 mL |
| 50 mM | 0.0529 mL | 0.2643 mL | 0.5285 mL |
Description
JNJ-632 is a potent assembly modulator (CAM) with mean EC50 of 121 nM in HepG2.2.15 cells.
Targets
| HBV capsid [1] (in HepG2.2.15 cells) |
| 121 nM(EC50) |
In vitro
JNJ-632 shows similar anti-HBV activities across all four genotypes tested, with the EC50s for genotypes A to D being 101, 240, 119, and 200 nM, respectively, by preventing formation of covalently closed circular DNA in a dose-dependent fashion.
References
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