[CAS NO. 808118-40-3] Roxadustat (FG-4592)

Name: Roxadustat (FG-4592)
Brand: Arctom Scientific
SKU: SLK-S1007

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PRODUCTS SPECIFICATIONS [808118-40-3]

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Catalog

SLK-S1007

Brand

Selleck

CAS

808118-40-3

DESCRIPTION [808118-40-3]

Overview

MDL	-
Molecular Weight	352.34
Molecular Formula	C19H16N2O5
SMILES	CC=1C2=C(C(O)=C(C(NCC(O)=O)=O)N1)C=CC(OC3=CC=CC=C3)=C2

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.8382 mL	14.1908 mL	28.3817 mL
5 mM	0.5676 mL	2.8382 mL	5.6763 mL
10 mM	0.2838 mL	1.4191 mL	2.8382 mL
50 mM	0.0568 mL	0.2838 mL	0.5676 mL

Description

Roxadustat (FG-4592) is an prolyl hydroxylase inhibitor in a cell-free assay, stabilizes HIF-2 and induces EPO production. Roxadustat potentiates RSL3 induced . Phase 3.

Targets

HIF α prolyl hydroxylase ^[1]
(Cell-free assay)

In vitro

FG-4592 is an oral inhibitor of hypoxia inducible factor (HIF) prolyl hydroxylase currently in clinical development for the treatment of anemia. FG-4592 stabilizes the activities of HIF, a cytosolic transcription factor, leading to activation of the genes associated with erythropoiesis, including erythropoietin and enzymes involved in iron metabolism.

References

[1] Seeley, TW, et al. U.S. Pat. Appl. Publ. 2007, US 20070292433 A1 20071220.
[2] Wu K, et al. Brain Res. 2016 Feb 1;1632:19-26.

Synonyms

Glycine, N-[(4-hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]-

N-[(4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]glycine

[[(4-Hydroxy-1-methyl-7-phenoxyisoquinolin-3-yl)carbonyl]amino]acetic acid

FG 4592

ASP 1517

Roxadustat

(4-Hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)glycine

[(4-Hydroxy-1-methyl-7-phenoxyisoquinolin-3-yl)carbonyl]glycine