[CAS NO. 364782-34-3] Cinacalcet (AMG-073) HCl

Name: Cinacalcet (AMG-073) HCl
Brand: Arctom Scientific
SKU: SLK-S1260

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PRODUCTS SPECIFICATIONS [364782-34-3]

Store

Catalog

SLK-S1260

Brand

Selleck

CAS

364782-34-3

DESCRIPTION [364782-34-3]

Overview

MDL	MFCD08067750
Molecular Weight	393.87
Molecular Formula	C22H22F3N.HCl
SMILES	[C@@H](NCCCC1=CC(C(F)(F)F)=CC=C1)(C)C=2C3=C(C=CC2)C=CC=C3.Cl

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.5389 mL	12.6945 mL	25.3891 mL
5 mM	0.5078 mL	2.5389 mL	5.0778 mL
10 mM	0.2539 mL	1.2695 mL	2.5389 mL
50 mM	0.0508 mL	0.2539 mL	0.5078 mL

Description

Cinacalcet (Mimpara, Sensipar,AMG-073) HCl represents a new class of compounds for the treatment of hyperparathyroidism.

Targets

CaSR ^[1]

2.8 μM(EC50)

In vitro

AMG-073 represents a new class of compounds for the treatment of hyperparathyroidism known as calcimimetics, which reduce parathyroid hormone (PTH) synthesis and secretion by increasing the sensitivity of the parathyroid calcium-sensing receptor (CaR) to extracellular calcium. AMG-073 has potential advantages as a therapy for secondary hyperparathyroidism because it mimics the effects of extracellular calcium to suppress PTH secretion, even in the presence of hyperphosphatemia, without the risk of causing hypercalcemia and/or hyperphosphatemia. AMG-073 produces a concentration-dependent increase in cytoplasmic calcium in human embryonic kidney cells expressing the CaSR. In bovine parathyroid cells and a buffer containing calcium 0.5 mM, AMG 073 (3 nM – 1 μM) produces a concentration-dependent decrease in PTH levels with IC50 of 27 nM.

References

[1] Ure?a P, et al. Kidney Int Suppl, 2003, (85), S91-96.
[2] Dong BJ. Clin Ther, 2005, 27(11), 1725-1751.

Synonyms

1-Naphthalenemethanamine, α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-, hydrochloride (1:1), (αR)-

1-Naphthalenemethanamine, α-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-, hydrochloride, (αR)-

AMG 073 HCl

Cinacalcet hydrochloride

KRN 1493

Sensipar

Mimpara

Regpara

N-[(1R)-1-(1-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine hydrochloride

[(1R)-1-(Naphthalen-1-yl)ethyl]([3-[3-(trifluoromethyl)phenyl]propyl])amine hydrochloride