[CAS NO. 111406-87-2] Zileuton (A-64077)

Name: Zileuton (A-64077)
Brand: Arctom Scientific
SKU: SLK-S1443

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PRODUCTS SPECIFICATIONS [111406-87-2]

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Catalog

SLK-S1443

Brand

Selleck

CAS

111406-87-2

DESCRIPTION [111406-87-2]

Overview

MDL	MFCD00866097
Molecular Weight	236.29
Molecular Formula	C11H12N2O2S
SMILES	C(N(C(N)=O)O)(C)C1=CC=2C(S1)=CC=CC2

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	4.2321 mL	21.1604 mL	42.3209 mL
5 mM	0.8464 mL	4.2321 mL	8.4642 mL
10 mM	0.4232 mL	2.1160 mL	4.2321 mL
50 mM	0.0846 mL	0.4232 mL	0.8464 mL

Description

Zileuton (A-64077, Abbott 64077, ZYFLO) is an orally active inhibitor of , and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation, used to decrease the symptoms of asthma. Zileuton induces while inhibits .

Targets

Ferroptosis ^[6]

5-lipoxygenase ^[1]

In vitro

Zileuton suppresses PG biosynthesis by interference with arachidonic acid (AA) release in macrophages. Zileuton significantly reduces PGE2 and 6-keto prostaglandin F1α (PGF1α) levels in activated mouse peritoneal macrophages and in J774 macrophages. Zileuton inhibits PGE2 production in LPS-stimulated human whole blood and suppresses PGE2 and 6-keto PGF1α pleural levels in rat carrageenan-induced pleurisy.

References

[1] Rossi A1, et al. Br J Pharmacol, 2010, 161(3), 555-570.
[2] Bertr醤 X, et al. Gut, 1996, 38(6), 899-904.
[3] Genovese T, et al. Br J Pharmacol, 2008, 153(3), 568-582.
[4] Patel NS, et al. Mol Pharmacol, 2004, 66(2), 220-227.
[5] Rao NL, et al. J Pharmacol Exp Ther, 2007, 321(3), 1154-1160.
[6] Yang Liu, et al. Biol Pharm Bull . 2015;38(8):1234-9.

Synonyms

Urea, N-(1-benzo[b]thien-2-ylethyl)-N-hydroxy-

N-(1-Benzo[b]thien-2-ylethyl)-N-hydroxyurea

Zileuton

A 64077

Abbott 64077

Zyflo

Leutrol

Griluto-CR

1-[1-(1-Benzothiophen-2-yl)ethyl]-1-hydroxyurea