[CAS NO. 302-79-4] Tretinoin (NSC 122758)

Name: Tretinoin (NSC 122758)
Brand: Arctom Scientific
SKU: SLK-S1653

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [302-79-4]

Store

Catalog

SLK-S1653

Brand

Selleck

CAS

302-79-4

DESCRIPTION [302-79-4]

Overview

MDL	MFCD00001551
Molecular Weight	300.4
Molecular Formula	C20H28O2
SMILES	C(=C/C(=C/C=C/C(=C/C(O)=O)/C)/C)\C=1C(C)(C)CCCC1C

For research use only.

Storage

3 years -20°C(in the dark) powder
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.3289 mL	16.6445 mL	33.2889 mL
5 mM	0.6658 mL	3.3289 mL	6.6578 mL
10 mM	0.3329 mL	1.6644 mL	3.3289 mL
50 mM	0.0666 mL	0.3329 mL	0.6658 mL

Description

Tretinoin (Retinoic acid, All-trans Retinoic Acid, ATRA, Vitamin A acid, Vesanoid, Airol, Renova, Atralin, Retin-A, Avita, Stieva-A,NSC 122758), which is a ligand for both , can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells.

Targets

RAR ^[1]

RXR ^[1]

In vitro

Tretinoin prevents the cytotoxicity of H2O2 in cultured human mesangial cells by increasing both the catalase activity and the reduced glutathione content, which are dose- and time-dependent changes. Tretinoin-incubated mesangial cells leads to increased levels of catalase mRNA and gamma-glutamyl-cysteine synthetase (catalytic subunit) mRNA, the latter being the rate-limiting step in de novo reduced glutathione synthesis. Tretinoin upregulates matrix metalloproteinase-13 and matrix metalloproteinase-8 in human keloid-derived fibroblasts.

References

[1] Manzano VM, et al. J Pharmacol Exp Ther, 1999, 289(1), 123-132.
[2] Uchida G, et al. Exp Dermatol, 2003, 12 ,Suppl 2, 35-42.
[3] Schwartz E, et al. J Invest Dermatol, 1994, 102(2), 241-246.
[4] Solis RR, et al. Dermatol Surg, 2002, 28(1), 83-6, discussion 86-87.
[5] Muehlberger T, et al. J Am Acad Dermatol, 2005, 52(4), 583-588.
[6] Zimmerman MW, et al. Sci Adv. 2021 Oct 22;7(43):eabe0834.
[7] Schwartz E, et al. J Invest Dermatol. 1995 Apr;104(4):518-22.

Synonyms

Retinoic acid

Retinoic acid, all-trans-

Vitamin A acid

Tretinoin

trans-Retinoic acid

2,4,6,8-Nonatetraenoic acid, 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (all-E)-

all-trans-Vitamin A acid

Vitamin A acid, all-trans-

Vitamin A₁ acid, all-trans-

3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid

β-Retinoic acid

(all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid

all-trans-Tretinoin

all-(E)-Retinoic acid

Tretin M

all-trans-β-Retinoic acid

Ro 1-5488

Retin A

AGN 100335

Aberel

all-trans-Retinoic acid

Vesanoid

ATRA

Renova

Atragen

Vesnaroid

Epi-Aberel

Cordes Vas

Dermairol

Aknoten

Airol

NSC 122578

Eudyna

Retacnyl

NSC 122758