[CAS NO. 83-43-2] Methylprednisolone (NSC-19987)

Name: Methylprednisolone (NSC-19987)
Brand: Arctom Scientific
SKU: SLK-S1733

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PRODUCTS SPECIFICATIONS [83-43-2]

Store

Catalog

SLK-S1733

Brand

Selleck

CAS

83-43-2

DESCRIPTION [83-43-2]

Overview

MDL	-
Molecular Weight	374.47
Molecular Formula	C22H30O5
SMILES	C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C([C@@H](C)C3)=CC(=O)C=C4)([C@@H](O)C1)[H])[H])(CC[C@@]2(C(CO)=O)O)[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.6704 mL	13.3522 mL	26.7044 mL
5 mM	0.5341 mL	2.6704 mL	5.3409 mL
10 mM	0.2670 mL	1.3352 mL	2.6704 mL
50 mM	0.0534 mL	0.2670 mL	0.5341 mL

Description

Methylprednisolone (NSC-19987,U 7532) is a synthetic agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates and reduces levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces and .

Targets

Glucocorticoid receptor ^[1]

In vitro

Methylprednisolone (2-10 mg/kg) markedly inhibits TNF production but does not affect serum levels of IL-10, while a high methylprednisolone dose (50 mg/kg) increases LPS-induced IL-10 levels. Methylprednisolone(from 0.01 to 100 mg/mL) also increases the biosynthesis of IL-10 by LPS-activated mouse peritoneal macrophages.

References

[1] A Marchant, et al. Clin Exp Immunol. 1996 Oct;106(1):91-6.
[2] Ricarda Diem, et al. J Neurosci. 2003 Aug 6;23(18):6993-7000.
[3] M Oudega, et al. Eur J Neurosci. 1999 Jul;11(7):2453-64.
[4] J Xu, et al. Brain Res Mol Brain Res. 1998 Aug 31;59(2):135-42.

Synonyms

Pregna-1,4-diene-3,20-dione, 11,17,21-trihydroxy-6-methyl-, (6α,11β)-

Pregna-1,4-diene-3,20-dione, 11β,17,21-trihydroxy-6α-methyl-

(6α,11β)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione

Medrol

Medrone

Δ¹-6α-Methylhydrocortisone

Methylprednisolone

6α-Methylprednisolone

Metrisone

11β,17,21-Trihydroxy-6α-methylpregna-1,4-diene-3,20-dione

11β,17α,21-Trihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione

Urbason

Urbasone

Wyacort

6α-Methyl-11β,17α,21β-trihydroxy-1,4-pregnadiene-3,20-dione

Dopomedrol

Besonia

Promacortine

Metastab

Metilbetasone

Medesone

Medrate

Moderin

Noretona

Urbazone

Metipred

U 7532

Methypred

Suprametil

NSC 19987

A-Methapred

Medorol

Medralone

M-Prednisol

Duralone

Prednol

Prednol L

Solimedrol

Metilprednisolone

SW 196788