[CAS NO. 144701-48-4] Telmisartan

Name: Telmisartan
Brand: Arctom Scientific
SKU: SLK-S1738

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PRODUCTS SPECIFICATIONS [144701-48-4]

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Catalog

SLK-S1738

Brand

Selleck

CAS

144701-48-4

DESCRIPTION [144701-48-4]

Overview

MDL	MFCD00918125
Molecular Weight	514.62
Molecular Formula	C33H30N4O2
SMILES	C(N1C=2C(N=C1CCC)=C(C)C=C(C2)C=3N(C)C=4C(N3)=CC=CC4)C5=CC=C(C=C5)C6=C(C(O)=O)C=CC=C6

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.9432 mL	9.7159 mL	19.4318 mL
5 mM	0.3886 mL	1.9432 mL	3.8864 mL
10 mM	0.1943 mL	0.9716 mL	1.9432 mL
50 mM	-	-	-

Description

Telmisartan (BIBR 277) is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.

Targets

angiotensin II receptor ^[1]

In vitro

Telmisartan functions as a moderately potent (EC50=4.5 μM), selective PPARγ partial agonist, activating the receptor to 25% to 30% of the maximum level achieved by the full agonists pioglitazone and rosiglitazone. Telmisartan induces adipocyte differentiation of 3T3-L1 cells. Telmisartan causes a 60% to 70% decrease in the expression of ACC2 in murine muscle myotubes. Telmisartan, but not candesartan, another ARB, downregulates RAGE mRNA levels in a dose-dependent manner. Telmisartan decreases basal as well as AGE-induced RAGE protein expression in Hep3B cells. Telmisartan dose-dependently inhibits AGE-induced ROS generation and subsequent CRP gene and protein induction in Hep3B cells. Telmisartan effectively facilitates differentiation of 3T3-L1 preadipocytes. Telmisartan causes a dose-dependent increase in mRNA levels for PPARgamma target genes such as aP2 and adiponectin in both differentiating adipocytes and fully differentiated adipocytes. Telmisartan attenuates 11beta-hydroxysteroid dehydrogenase type 1 mRNA level in differentiated adipocytes.

In vivo

Telmisartan promotes increases in caloric expenditure and protects against dietary-induced weight gain in rats fed with a high-fat, high-carbohydrate diet. Telmisartan reduces the accumulation of visceral fat and decreases adipocyte size to a much greater extent than valsartan and is also associated with a significant reduction in hepatic triglyceride levels in rats fed with a high-fat, high-carbohydrate diet.

References

[1] Benson SC, et al. Hypertension, 2004, 43(5), 993-1002.
[2] Yoshida T, et al. Diabetologia, 2006, 49(12), 3094-3099.
[3] Fujimoto M, et al. FEBS Lett, 2004, 576(3), 492-497.
[4] Sugimoto K et al. Hypertension, 2006, 47(5), 1003-1009.

Synonyms

[1,1′-Biphenyl]-2-carboxylic acid, 4′-[(1,4′-dimethyl-2′-propyl[2,6′-bi-1H-benzimidazol]-1′-yl)methyl]-

4′-[(1,4′-Dimethyl-2′-propyl[2,6′-bi-1H-benzimidazol]-1′-yl)methyl][1,1′-biphenyl]-2-carboxylic acid

BIBR 277

Telmisartan

4′-[[4-Methyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimidazolyl]methyl]-2-biphenylcarboxylic acid

BIBR 277SE

Micardis

Pritor

Telday

Kinzalmono

Telsar

Telsite

Telmisartar

2-[4-[[4-Methyl-6-(1-methylbenzimidazol-2-yl)-2-propylbenzimidazol-1-yl]methyl]phenyl]benzoic acid

2-(4-[[4-Methyl-6-(1-methyl-1H-1,3-benzodiazol-2-yl)-2-propyl-1H-1,3-benzodiazol-1-yl]methyl]phenyl)benzoic acid

Tolura

Semintra