[CAS NO. 147098-20-2] Rosuvastatin (ZD4522) calcium

Name: Rosuvastatin (ZD4522) calcium
Brand: Arctom Scientific
SKU: SLK-S2169

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PRODUCTS SPECIFICATIONS [147098-20-2]

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Catalog

SLK-S2169

Brand

Selleck

CAS

147098-20-2

DESCRIPTION [147098-20-2]

Overview

MDL	MFCD04112702
Molecular Weight	500.57
Molecular Formula	C22H28FN3O6S.1/2Ca
SMILES	C(=C/[C@H](C[C@H](CC(O)=O)O)O)\C=1C(=NC(N(S(C)(=O)=O)C)=NC1C(C)C)C2=CC=C(F)C=C2.[Ca]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.9977 mL	9.9886 mL	19.9772 mL
5 mM	0.3995 mL	1.9977 mL	3.9954 mL
10 mM	0.1998 mL	0.9989 mL	1.9977 mL
50 mM	0.0400 mL	0.1998 mL	0.3995 mL

Description

Rosuvastatin Calcium (ZD4522 calcium) is a competitive inhibitor of with of 11 nM in a cell-free assay.

Targets

HMG-CoA reductase ^[2]
(Cell-free assay)

11 nM

In vitro

Rosuvastatin is relatively hydrophilic and is highly selective for hepatic cells; its uptake is mediated by the liver-specific organic anion transporter OATP-C. Rosuvastatin is a high-affinity substrate for OATP-C with apparent association constant of 8.5 μM. Rosuvastatin inhibits cholesterol biosynthesis in rat liver isolated hepatocytes with IC50 of 1.12 nM. Rosuvastatin causes approximately 10 times greater increase of mRNA of LDL receptors than pravastatin. Rosuvastatin (100 μM) decreases the extent of U937 adhesion to TNF-α-stimulated HUVEC. Rosuvastatin inhibits the expressions of ICAM-1, MCP-1, IL-8, IL-6, and COX-2 mRNA and protein levels through inhibition of c-Jun N-terminal kinase and nuclear factor-kB in endothelial cells.

References

[1] Schneck DW, et al. Clin Pharmacol Ther, 2004, 75(5), 4554-63.
[2] Watanabe M, et al. Bioorg Med Chem, 1997, 5(2), 437-444.
[3] Kim YS, et al. J Cardiovasc Pharmacol, 2007, 49(6), 376-383.
[4] Carswell CI, et al. Drugs, 2002, 62(14), 2075-2085
[5] Stalker TJ, et al. Br J Pharmacol, 2001, 133(3), 406-412.
[6] Sch?fer A, et al. Biochem Pharmacol, 2007, 73(9), 1367-1375.
[7] Bulhak AA, et al. Acta Physiol Scand, 2005, 183(2), 151-159.
[8] Custodis F, et al. Cardiovasc Res, 2006 Jul 15, 71(2), 342-351.
[9] Dansette PM, et al. Exp Toxicol Pathol, 2000, 52(2), 145-148.
[10] Jang HJ, et al. Cancers (Basel). 2021 Nov 4;13(21):5543.
[11] Chen A, et al. Cell Death Dis. 2021 Jan 12;12(1):78.

Synonyms

6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-, calcium salt (2:1), (3R,5S,6E)-

6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-, calcium salt (2:1), [S-[R*,S*-(E)]]-

Rosuvastatin calcium

S 4522

ZD 4522, calcium salt

Rosuvastatin hemicalcium

Crestor

Rosuvastatin calcium salt

Fortius

Rostar

Rozavel

Crestomed

Suvikan

Razel-F 10

AZD 4522 calcium

AZD4522 calcium

AZD-4522 calcium