[CAS NO. 882663-88-9] AMG-47a
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PRODUCTS SPECIFICATIONS [882663-88-9]
Store
Catalog
SLK-S2213
Brand
Selleck
CAS
882663-88-9
DESCRIPTION [882663-88-9]
Overview
| MDL | MFCD09970318 |
|---|---|
| Molecular Weight | 535.56 |
| Molecular Formula | C29H28F3N5O2 |
| SMILES | O=C(NC1=CC=CC(C(F)(F)F)=C1)C2=CC=C(C)C(C3=CC4=CN=C(NCCN5CCOCC5)N=C4C=C3)=C2 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.8672 mL | 9.3360 mL | 18.6720 mL |
| 5 mM | - | - | - |
| 10 mM | - | - | - |
| 50 mM | - | - | - |
Description
AMG-47a is a potent, nonselective inhibitor of with IC50 of 3.4 uM and it also inhibits T cell proliferation. AMG-47a exhibit anti-inflammatory activity (ED50) of 11 mg/kg in the anti-CD3-induced production of interleukin-2 (IL-2) in mice.
Targets
| LCK [1] (Cell-free assay) |
| 3.4 μM |
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