[CAS NO. 568-73-0] Tanshinone I
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PRODUCTS SPECIFICATIONS [568-73-0]
Store
Catalog
SLK-S2364
Brand
Selleck
CAS
568-73-0
DESCRIPTION [568-73-0]
Overview
| MDL | MFCD00210563 |
|---|---|
| Molecular Weight | 276.29 |
| Molecular Formula | C18H12O3 |
| SMILES | O=C1C=2C(C3=C(C1=O)C(C)=CO3)=CC=C4C2C=CC=C4C |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.6194 mL | 18.0969 mL | 36.1939 mL |
| 5 mM | 0.7239 mL | 3.6194 mL | 7.2388 mL |
| 10 mM | 0.3619 mL | 1.8097 mL | 3.6194 mL |
| 50 mM | 0.0724 mL | 0.3619 mL | 0.7239 mL |
Description
Tanshinone I, an active principle isolated from Salvia miltiorrhiza (Danshen), is structurally similar to tanshinone IIA and may possess similar cytotoxic effects on tumor cells.
Targets
| PLA2 [1] |
| 11 μM |
In vitro
Tanshinone I, an active principle isolated from Salvia miltiorrhiza (Danshen), is structurally similar to tanshinone IIA and may possess similar cytotoxic effects on tumor cells. Tanshinone I inhibits PGE formation from LPS-induced RAW macrophages (IC50 = 38 μM). However, this compound does not affect COX-2 activity or COX-2 expression. Tanshinone I is an inhibitor of type IIA human recombinant phospholipase A (PLA) with IC50 of 11 μM. In preliminary data, tanshinone I possesses the strongest inhibitory effect on tumor necrosis factor-α (TNF-α)-induced adhesion molecules.
References
Synonyms
Phenanthro[1,2-b]furan-10,11-dione, 1,6-dimethyl-
1,6-Dimethylphenanthro[1,2-b]furan-10,11-dione
Tanshinone I
Tanshinon I
Tanshinone A
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