[CAS NO. 65914-17-2] Polydatin
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PRODUCTS SPECIFICATIONS [65914-17-2]
Store
Catalog
SLK-S2390
Brand
Selleck
CAS
65914-17-2
DESCRIPTION [65914-17-2]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 390.38 |
| Molecular Formula | C20H22O8 |
| SMILES | O([C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C2=CC(C=CC3=CC=C(O)C=C3)=CC(O)=C2 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.5616 mL | 12.8080 mL | 25.6161 mL |
| 5 mM | 0.5123 mL | 2.5616 mL | 5.1232 mL |
| 10 mM | 0.2562 mL | 1.2808 mL | 2.5616 mL |
| 50 mM | 0.0512 mL | 0.2562 mL | 0.5123 mL |
Description
Polydatin (Piceid) is a crystal component extracted from the root stem of perennial herbage Polygonum Cuspidatum Sieb.et Zucc.
Targets
| PLA2 [1] |
In vitro
Polydatin, known as a PLA2 inhibitor, reduces Phospholipase A2 (PLA2) activity and sPLA2-IIA mRNA expression and mitigates LPS-induced lung injury by increasing increased Clara cell secretory protein (CCSP) expression.
In vivo
Pretreatment with Polydatin (15, 45, and 100 mg/kg) dose-dependently reduces sepsis-induced mortality and lung injury in cecal ligation and puncture (CLP-)induced sepsis mice through inhibiting CLP-induced serum tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) production, lung cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase isoform (iNOS) protein expressions and NF-kappaB activation. LD50: Mice 1g/kg (i.p.)
References
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