[CAS NO. 478-43-3] Rheic Acid

Name: Rheic Acid
Brand: Arctom Scientific
SKU: SLK-S2400

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PRODUCTS SPECIFICATIONS [478-43-3]

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Catalog

SLK-S2400

Brand

Selleck

CAS

478-43-3

DESCRIPTION [478-43-3]

Overview

MDL	MFCD00009618
Molecular Weight	284.22
Molecular Formula	C15H8O6
SMILES	O=C1C=2C(C(=O)C=3C1=C(O)C=CC3)=CC(C(O)=O)=CC2O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.5184 mL	17.5920 mL	35.1840 mL
5 mM	0.7037 mL	3.5184 mL	7.0368 mL
10 mM	0.3518 mL	1.7592 mL	3.5184 mL
50 mM	-	-	-

Description

Rhein (Monorhein, NSC 38629, Rheinic) is an anthraquinone compound enriched in the fresh rhizome of Rheum coreanum Nakai, showing anti-inflammation and antitumor activities. Rhein is an inhibitor and also inhibits .

In vitro

Rhein at 35 μM can effectively inhibit the synthesis of IL-1β on human osteoarthritis synovium, as well as the action of this cytokine at the cartilage level, by reducing the number of chondrocyte IL-1R and inhibiting IL-1β induced NO production in chondrocytes and cartilage. Rhein also induces apoptosis in human promyelocytic leukemia cells (HL-60), characterized by caspase activation, poly(ADP)ribose polymerase (PARP) cleavage, and DNA fragmentation.

In vivo

Rhein is also effective in ameliorating diabetic renal pathological changes and attenuating hyperlipidemia in db/db mice with diabetic nephropathy with decreased transforming growth factor-beta1 (TGF-beta1) and fibronectin immunohistochemistry expression in renal tissue and reduced cholesterol (Chol), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and ApoE in plasma.

References

[1] Martel-Pelletier J, et al. J Rheumatol, 1998, 25(4), 753-762.
[2] Pelletier JP, et al. J Rheumatol, 1998, 25(12), 2417-2424.
[3] Lin S, et al. Arch Biochem Biophys, 2003, 418(2), 99-107.
[4] Gao Q, et al. Planta Med, 2010, 76(1), 27-33.

Synonyms

2-Anthracenecarboxylic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-

2-Anthroic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-

2-Anthraquinonecarboxylic acid, 4,5-dihydroxy-

9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid

Cassic acid

Chrysazin-3-carboxylic acid

1,8-Dihydroxyanthraquinone-3-carboxylic acid

Monorhein

Rheic acid

Rhein

Rhubarb yellow

4,5-Dihydroxy-2-anthraquinonecarboxylic acid

1,8-Dihydroxy-3-carboxyanthraquinone

NSC 38629

Rheinic acid