[CAS NO. 961-29-5] Isoliquiritigenin

Name: Isoliquiritigenin
Brand: Arctom Scientific
SKU: SLK-S2404

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PRODUCTS SPECIFICATIONS [961-29-5]

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Catalog

SLK-S2404

Brand

Selleck

CAS

961-29-5

DESCRIPTION [961-29-5]

Overview

MDL	MFCD00075907
Molecular Weight	256.25
Molecular Formula	C15H12O4
SMILES	C(/C=C/C1=CC=C(O)C=C1)(=O)C2=C(O)C=C(O)C=C2

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.9024 mL	19.5122 mL	39.0244 mL
5 mM	0.7805 mL	3.9024 mL	7.8049 mL
10 mM	0.3902 mL	1.9512 mL	3.9024 mL
50 mM	0.0780 mL	0.3902 mL	0.7805 mL

Description

Isoliquiritigenin, an anti-tumor flavonoid from the root of Glycyrrhiza glabra, inhibits with an IC50 of 320 nM.

Targets

Aldose reductase ^[1]
(Cell-free assay)

320 nM

In vitro

Isoliquiritigenin may be effective in preventing diabetic complications through inhibiting rat lens aldose reductase with an IC50 of 320 nM and sorbitol accumulation in human red blood cells with an IC50 of 2.0 μM. Isoliquiritigenin may also serve as a skin-lightening agent by inhibiting mono- and diphenolase tyrosinase activities with an IC50 of 8.1 μM. Isoliquiritigenin induces cell cycle arrest and cell growth inhibition in DU145 and LNCaP prostate cancer cell lines. Isoliquiritigenin induces apoptosis of human gastric cancer MGC-803 cells through increasing the intracellular free calcium concentration and decreasing the mitochondrial transmembrane potential (Deltapsi(m)).

In vivo

LD50: Mice >6g/kg (i.g.)

References

[1] Aida K, et al. Planta Med, 1990, 56(3), 254-258.
[2] Nerya O, et al. J Agric Food Chem, 2003, 51(5), 1201-1207.
[3] Kanazawa M, et al. Eur Urol, 2003, 43(5), 580-586.
[4] Ma J, et al. Planta Med, 2001, 67(8), 754-757.
[5] Chen G, et al. Phytother Res, 2009, 23(4), 498-506.

Synonyms

2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-, (2E)-

Chalcone, 2′,4,4′-trihydroxy-

2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-, (E)-

(2E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one

Isoliquiritigenin

2′,4,4′-Trihydroxychalcone

GU 17

Isoliquiritigen

(E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one