[CAS NO. 221243-82-9] 1-Naphthyl PP1(1-NA-PP1)

Name: 1-Naphthyl PP1(1-NA-PP1)
Brand: Arctom Scientific
SKU: SLK-S2642

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PRODUCTS SPECIFICATIONS [221243-82-9]

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Catalog

SLK-S2642

Brand

Selleck

CAS

221243-82-9

DESCRIPTION [221243-82-9]

Overview

MDL	MFCD03425471
Molecular Weight	317.39
Molecular Formula	C19H19N5
SMILES	NC1=C2C(=NN(C(C)(C)C)C2=NC=N1)C=3C4=C(C=CC3)C=CC=C4

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.1507 mL	15.7535 mL	31.5070 mL
5 mM	0.6301 mL	3.1507 mL	6.3014 mL
10 mM	0.3151 mL	1.5753 mL	3.1507 mL
50 mM	-	-	-

Description

1-Naphthyl PP1(1-NA-PP 1) is a highly selective and potent inhibitor with IC50 of 154.6 nM,133.4 nM and 109.4 nM for PKD1, PKD2 and PKD3, respectively. 1-Naphthyl PP1 is a selective inhibitor of and with IC50 of 1.0 μM, 0.6 μM, 0.6 μM, 18 μM and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II, respectively.

Targets

References

[1] Tandon M, et al. PLoS One. 2013 Sep 23;8(9):e75601.
[2] Bishop AC, et al. Nature. 2000 Sep 21;407(6802):395-401.

Synonyms

1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-(1,1-dimethylethyl)-3-(1-naphthalenyl)-

1-(1,1-Dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

1-NA-PP 1

1-Naphthyl PP 1

1-tert-Butyl-3-naphthalen-1-ylpyrazolo[3,4-d]pyrimidin-4-amine

PP1 analog