[CAS NO. 278779-30-9] GW4064
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PRODUCTS SPECIFICATIONS [278779-30-9]
Store
Catalog
SLK-S2782
Brand
Selleck
CAS
278779-30-9
DESCRIPTION [278779-30-9]
Overview
| MDL | MFCD09971006 |
|---|---|
| Molecular Weight | 542.84 |
| Molecular Formula | C28H22Cl3NO4 |
| SMILES | C(OC1=CC(Cl)=C(C=CC2=CC(C(O)=O)=CC=C2)C=C1)C=3C(=NOC3C(C)C)C4=C(Cl)C=CC=C4Cl |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.8422 mL | 9.2108 mL | 18.4216 mL |
| 5 mM | 0.3684 mL | 1.8422 mL | 3.6843 mL |
| 10 mM | 0.1842 mL | 0.9211 mL | 1.8422 mL |
| 50 mM | 0.0368 mL | 0.1842 mL | 0.3684 mL |
Description
GW4064 is an agonist of with EC50 of 65 nM in CV1 cell line and displays no activity at other nuclear receptors at concentrations up to 1 μM. GW4064 stimulates in MCF-7 cells.
Targets
| FXR [1] (CV1) |
| 65 nM(EC50) |
In vitro
GW 4064 is a full agonist with EC50 values of 80 and 90 nM, respectively, in CV-1 cells transfected with mouse and human FXR expression vectors and an established reporter gene. There is no activity of GW 4064 on other nuclear receptors, including the retinoic acid receptor, at concentrations up to 1 μM. Thus, GW 4064 is a potent and selective nonsteroidal FXR agonist.
References
Synonyms
Benzoic acid, 3-[2-[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]ethenyl]-
3-[2-[2-Chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]ethenyl]benzoic acid
GW 4064
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