[CAS NO. 1224844-38-5] Sapanisertib (MLN0128)

Name: Sapanisertib (MLN0128)
Brand: Arctom Scientific
SKU: SLK-S2811

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [1224844-38-5]

Store

Catalog

SLK-S2811

Brand

Selleck

CAS

1224844-38-5

DESCRIPTION [1224844-38-5]

Overview

MDL	MFCD22124893
Molecular Weight	309.33
Molecular Formula	C15H15N7O
SMILES	NC1=C2C(=NN(C(C)C)C2=NC=N1)C=3C=C4C(=CC3)OC(N)=N4

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.2328 mL	16.1640 mL	32.3279 mL
5 mM	0.6466 mL	3.2328 mL	6.4656 mL
10 mM	0.3233 mL	1.6164 mL	3.2328 mL
50 mM	0.0647 mL	0.3233 mL	0.6466 mL

Description

Sapanisertib (MLN0128, INK 128, TAK-228) is a potent and selective inhibitor with of 1 nM in cell-free assays; >200-fold less potent to class I PI3K isoforms, superior in blocking mTORC1/2 and sensitive to pro-invasion genes (vs Rapamycin). Phase 1.

Targets

In vitro

INK 128 exhibits an enzymatic inhibition activity against mTOR and more than 100-fold selectivity to PI3K kinases. As TORC1/2 inhibitor, INK 128 inhibits both the phosphorylation of S6 and 4EBP1, the downstream substrates of TORC1, and selectively inhibits AKT phosphorylation at Ser473, the downstream substrate of TORC2. Furthermore, INK 128 also shows potent inhibition effects on cell lines resistant to rapamycin and pan-PI3K inhibitors.

References

[1] Liu A, et al. Drug Discovery Today: Therapeutic Strategies. 2009, 6(2), 47-55.
[2] Jessen K, et al. Mol Cancer Ther. 2009, 8(12), Meeting Abstract Supplement.
[3] Hsieh AC, et al. Nature. 2012, 485(7396), 55-61.

Synonyms

1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-(2-amino-5-benzoxazolyl)-1-(1-methylethyl)-

3-(2-Amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

INK 128

MLN 0128

Sapanisertib

TAK 228