[CAS NO. 1223001-51-1] Torin 2
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PRODUCTS SPECIFICATIONS [1223001-51-1]
Store
Catalog
SLK-S2817
Brand
Selleck
CAS
1223001-51-1
DESCRIPTION [1223001-51-1]
Overview
| MDL | MFCD18782652 |
|---|---|
| Molecular Weight | 432.4 |
| Molecular Formula | C24H15F3N4O |
| SMILES | O=C1N(C2=CC=CC(C(F)(F)F)=C2)C3=C(C=NC4=CC=C(C5=CC=C(N)N=C5)C=C43)C=C1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3127 mL | 11.5634 mL | 23.1267 mL |
| 5 mM | 0.4625 mL | 2.3127 mL | 4.6253 mL |
| 10 mM | 0.2313 mL | 1.1563 mL | 2.3127 mL |
| 50 mM | 0.0463 mL | 0.2313 mL | 0.4625 mL |
Description
Torin 2 is a potent and selective inhibitor with of 0.25 nM in p53−/− MEFs cell line; 800-fold greater selectivity for mTOR than PI3K and improved pharmacokinetic properties. Inhibition of with of 28 nM/35 nM/118 nM,in PC3 cell lines respectively. Torin 2 decreases cell viability and induces and .
Targets
In vitro
Torin 2 has the same binding mode as PI3Kγ, V882 serves as a hinge binding point and in the inner hydrophobic pocket Y867, D841 and D964 provide three more hydrogen bonds with aminopyridine side chain analogous to Y2225, D2195 and D2357 of mTOR. Torin 2 inhibits mTORC1, thus activates TFEB by promoting its nuclear translocation with EC50 of 1.666 mM. Torin 2(< 50 nM) causes a significant reduction in viability of both MZ-CRC-1 and TT cells. Torin 2 (100 nM) exerts a significant reduction of migration of both MZ-CRC-1 and TT cells.
References
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