[CAS NO. 95233-18-4] Atovaquone

Name: Atovaquone
Brand: Arctom Scientific
SKU: SLK-S3079

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PRODUCTS SPECIFICATIONS [95233-18-4]

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Catalog

SLK-S3079

Brand

Selleck

CAS

95233-18-4

DESCRIPTION [95233-18-4]

Overview

MDL	MFCD00889188
Molecular Weight	366.84
Molecular Formula	C22H19ClO3
SMILES	O=C1C(=C(O)C(=O)C=2C1=CC=CC2)[C@H]3CC[C@@H](CC3)C4=CC=C(Cl)C=C4

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.7260 mL	13.6299 mL	27.2598 mL
5 mM	0.5452 mL	2.7260 mL	5.4520 mL
10 mM	0.2726 mL	1.3630 mL	2.7260 mL
50 mM	-	-	-

Description

Atovaquone (Atavaquone) is a medication used to treat or prevent for pneumocystis pneumonia, toxoplasmosis, malaria, and babesia.

In vitro

Atovaquone (atavaquone) is a chemical compound that belongs to the class of naphthalenes. Atovaquone is a hydroxy-1,4-naphthoquinone, an analog of ubiquinone, with antipneumocystic activity. Atovaquone is an anti-protozoal mitochondrial electron transport inhibitor; Antimalarial; Antipneumocystic, and has also been used to treat toxoplasmosis. It acts by inhibiting the cytochrome bc(1) complex via interactions with the Rieske iron-sulfur protein and cytochrome b in the ubiquinol oxidation pocket.

In vivo

Atovaquone is a unique naphthoquinone with broad-spectrum antiprotozoal activity. It is effective for the treatment and prevention of Pneumocystis carinii pneumonia (PCP), it is effective in combination with proguanil for the treatment and prevention of malaria, and it is effective in combination with azithromycin for the treatment of babesiosis.

References

[1] Looareesuwan S, et al. Am J Trop Med Hyg, 1996, 54(1), 62-66.
[2] Kessl JJ, et al. J Biol Chem, 2003, 278(33), 31312-31318.
[3] Aaron L, et al. Antimicrob Agents Chemother, 2002, 46(5), 1163-1173.

Synonyms

1,4-Naphthalenedione, 2-[trans-4-(4-chlorophenyl)cyclohexyl]-3-hydroxy-

1,4-Naphthalenedione, 2-[4-(4-chlorophenyl)cyclohexyl]-3-hydroxy-, trans-

2-[trans-4-(4-Chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthalenedione

566C80

566C

Atovaquone

Mepron

Mepron (antipneumocystic)

BW 556C-80

BW 566C

Acuvel

Wellvone

Meprone

Samtirel