[CAS NO. 1177-87-3] Dexamethasone Acetate

Name: Dexamethasone Acetate
Brand: Arctom Scientific
SKU: SLK-S3124

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PRODUCTS SPECIFICATIONS [1177-87-3]

Store

Catalog

SLK-S3124

Brand

Selleck

CAS

1177-87-3

DESCRIPTION [1177-87-3]

Overview

MDL	-
Molecular Weight	434.5
Molecular Formula	C24H31FO6
SMILES	C[C@@]12[C@]([C@]3([C@@](F)([C@]4(C)C(CC3)=CC(=O)C=C4)[C@@H](O)C1)[H])(C[C@@H](C)[C@@]2(C(COC(C)=O)=O)O)[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

Dexamethasone (NSC 39471,Dexamethasone 21-acetate) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an modulator that has anti-inflammatory and immunosuppressant effects.

Targets

interleukin receptor ^[1]

In vitro

Dexamethasone inhibits COX-2 mRNA expression induced by IL-1 in human articular chondrocytes. Dexamethasone suppresses the cyclooxygenase-2 induction by tumor necrosis factor α (TNFα) with an IC50 of 1 nM in MC3T3-E1 cells. Dexamethasone binds to the glucocorticoid receptor and then to the glucocorticoid response element. Dexamethasone (10 μM) induces osteoblastic differentiation of rat bone marrow stromal cell cultures with elevated mRNA expression of alkaline phosphatase osteopontin, bone sialoprotein, and osteocalcin. Dexamethasone (5 μM) treatment decreases proliferation of adult hippocampal neural progenitor cells and SRE-driven gene expression.

References

Blanco FJ, et al. J Rheumatol, 1999, 26(6), 1366-1373.
Yamamoto K, et al. FEBS Lett, 2000, 465(2-3), 103-106.
[3] Rickard DJ, et al. Dev Biol, 1994, 161(1), 218-228.
[4] Nagy P, et al. Hepatology, 1998, 28(2), 423-429.
[5] Kim JB, et al. Brain Res, 2004, 1027(1-2), 1-10.
[6] Wu CY, et al. J Immunol. 1998, 161(6), 2723-2730.

Synonyms

Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-9-fluoro-11,17-dihydroxy-16-methyl-, (11β,16α)-

Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16α-methyl-, 21-acetate

(11β,16α)-21-(Acetyloxy)-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione

Dex-Cortidelt acetate

16α-Methyl-9α-fluoroprednisolone 21-acetate

Dexamethasone 21-acetate

Fortecortin (crystal suspension)

Dexamethasone acetate

Fortecortin

Decadron LA

Dectancyl

Dexa-Cortisyl

Dalalone LA

Decadronal

Dalalone DP

NSC 39471