[CAS NO. 101152-94-7] Milnacipran HCl

Name: Milnacipran HCl
Brand: Arctom Scientific
SKU: SLK-S3140

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PRODUCTS SPECIFICATIONS [101152-94-7]

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Catalog

SLK-S3140

Brand

Selleck

CAS

101152-94-7

DESCRIPTION [101152-94-7]

Overview

MDL	MFCD00901293
Molecular Weight	282.81
Molecular Formula	C15H22N2O.HCl
SMILES	C(N(CC)CC)(=O)[C@]1([C@@H](CN)C1)C2=CC=CC=C2.Cl

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.5359 mL	17.6797 mL	35.3594 mL
5 mM	0.7072 mL	3.5359 mL	7.0719 mL
10 mM	0.3536 mL	1.7680 mL	3.5359 mL
50 mM	0.0707 mL	0.3536 mL	0.7072 mL

Description

Milnacipran inhibits both and norepinephrine transporter (SERT) with of 77 nM and 420 nM, respectively.

Targets

norepinephrine transporter (NET) ^[1]	norepinephrine transporter (SERT) ^[1]
77 nM	420 nM

In vitro

Milnacipran is mainly excreted in the urine as the parent and glucoronide (> 80%), and only a small fraction (< 10%) is metabolized via N-de-ethylation by the CYP3A4 enzyme. Milnacipran at high concentration can inhibit certain ligand-gated ion-channel (LGIC) receptors, including NMDA, 5-HT3A and nACh receptors, with IC50 of 58.4 μM, 185 μM, 14.3 μM.

In vivo

Milnacipran (10 and 30 mg/kg, PO) causes a dose-related increase in the extracellular levels of 5-HT and NA in the medial prefrontal cortex of rats. Milnacipran (30 and 60 mg/kg, PO) significantly reduces the duration of both the immobility time in the forced swimming test and the freezing time in the conditioned fear stress test in rats, which are animal behavioral models for depression and anxiety, respectively. Milnacipran (<40 mg/kg i.p.) dose-dependently increases the extracellular levels of NA and 5-HT in hypothalamus of freely moving guinea pigs. Milnacipran administrated at 10 mg/kg and 40 mg/kg decreases NA metabolite MHPG levels by 57% and 47%, respectively, in hypothalamus of freely moving guinea pigs.

References

[1] Chen C, et al. Bioorg Med Chem Lett, 2008, 18(4), 1346-1349.
[2] Ueta K, et al. Psychopharmacology (Berl), 2004, 175(2), 241-246.
[3] Mochizuki D, et al. Psychopharmacology (Berl), 2002, 162(3), 323-332.
[4] Moret C, et al. J Neurochem, 1997, 69(2), 815-822.

Synonyms

Cyclopropanecarboxamide, 2-(aminomethyl)-N,N-diethyl-1-phenyl-, hydrochloride (1:1), (1R,2S)-rel-

Cyclopropanecarboxamide, 2-(aminomethyl)-N,N-diethyl-1-phenyl-, monohydrochloride, cis-(±)-

Cyclopropanecarboxamide, 2-(aminomethyl)-N,N-diethyl-1-phenyl-, monohydrochloride, (1R,2S)-rel-

F 2207

Milnacipran hydrochloride

Cyclopropanecarboxamide, 2-(aminomethyl)-N,N-diethyl-1-phenyl-, monohydrochloride, cis-

Ixel

Dalcipran

Toledomin

Savella

Tivanyl

Joncia