[CAS NO. 130929-57-6] Entacapone

Name: Entacapone
Brand: Arctom Scientific
SKU: SLK-S3147

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PRODUCTS SPECIFICATIONS [130929-57-6]

Store

Catalog

SLK-S3147

Brand

Selleck

CAS

130929-57-6

DESCRIPTION [130929-57-6]

Overview

MDL	MFCD00866580
Molecular Weight	305.29
Molecular Formula	C14H15N3O5
SMILES	C(=C(/C(N(CC)CC)=O)\C#N)\C1=CC(N(=O)=O)=C(O)C(O)=C1

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

Entacapone (OR-611) inhibits with of 151 nM. Entacapone can be used for the research of Parkinson's disease. Entacapone serves as a inhibitor of with an IC50 of 3.5 μM, can be used for the research of metabolic disorders.

Targets

COMT ^[1]

151 nM

In vitro

Entacapone inhibits catechol-O-methyltransferase(COMT) with similar IC50 in different tissues including live, duodenum, kidney and lung, but entacapone is more active than tolcapone in those tissues. Entacapone (< 100 μM) is a potent inhibitor of α-syn and β-amyloid (Aβ) oligomerization and fibrillogenesis, and also protects against extracellular toxicity induced by the aggregation of both proteins in PC12 cells.

References

[1] De Santi C, et al. Eur J Clin Pharmacol, 1998, 54(3), 215-219.
[2] Di Giovanni S, et al. J Biol Chem, 2010, 285(20), 14941-14954.
[3] Jenner P, et al. Neurology, 2004, 62(1 Suppl 1), S47-55.
[4] Hamaue N, et al. Brain Res, 2010, 1309, 110-115.
[5] Peng S, et al. Sci Transl Med. 2019 Apr 17;11(488):eaau7116.

Synonyms

2-Propenamide, 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-, (2E)-

2-Propenamide, 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-, (E)-

(2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide

Entacapone

Comtan

OR 611

(E)-Entacapone

Entacom

Parkicapone

Comtess