[CAS NO. 549-18-8] Amitriptyline HCl

Name: Amitriptyline HCl
Brand: Arctom Scientific
SKU: SLK-S3183

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PRODUCTS SPECIFICATIONS [549-18-8]

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Catalog

SLK-S3183

Brand

Selleck

CAS

549-18-8

DESCRIPTION [549-18-8]

Overview

MDL	MFCD00012537
Molecular Weight	313.86
Molecular Formula	C20H23N.HCl
SMILES	C(CCN(C)C)=C1C=2C(CCC=3C1=CC=CC3)=CC=CC2.Cl

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.1861 mL	15.9307 mL	31.8613 mL
5 mM	0.6372 mL	3.1861 mL	6.3723 mL
10 mM	0.3186 mL	1.5931 mL	3.1861 mL
50 mM	0.0637 mL	0.3186 mL	0.6372 mL

Description

Amitriptyline HCl is an inhibitor of both and with Ki of 3.45 nM and 13.3 nM, respectively. Amitriptyline HCl also inhibits , , and with Ki of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. Amitriptyline is a tricyclic antidepressant (TCA).

Targets

In vitro

Amitriptyline inhibits Forskolin-stimulated cyclic AMP accumulation with EC50 values of 16.2 μM in intact CHO/DOR cells. Amitriptyline causes a concentration-dependent stimulation of ERK1/2 and GSK-3β phosphorylation with EC50 values of 9.0 μM in CHO/DOR cells. Amitriptyline (15 μM) causes a stimulation of ERK1/2 phosphorylation in C6 cells. Amitriptyline (30 μM) inhibits Forskolin-stimulated adenylyl cyclase activity and antagonizes (−)-U50,488 inhibitory effect in rat nucleus accumbens. Amitriptyline binds the extracellular domain of both TrkA and TrkB and promotes TrkA-TrkB receptor heterodimerization. Amitriptyline (< 500 nM) promotes TrkA autophosphorylation in primary neurons and induces neurite outgrowth in PC12 cells. Amitriptyline selectively protects T17 cells from apoptosis with EC50 of 50 nM.

References

[1] Vaishnavi SN, et al. Biol Psychiatry, 2004, 55(3), 320-322.
[2] Nguyen T, et al. Mol Pharmacol, 2001, 59(3), 427-433.
[3] Rauser L, et al. J Pharmacol Exp Ther, 2001, 299(1), 83-89.
[4] Werling LL, et al. Exp Neurol, 2007, 207(2), 248-257.
[5] Onali P, et al. J Pharmacol Exp Ther, 2010, 332(1), 255-265.
[6] Jang SW, et al. Chem Biol, 2009, 16(6), 644-656.
[7] Ushijima K, et al. J Pharmacol Exp Ther, 2005, 315(2), 764-770.
[8] Troelsen KB, et al. Psychopharmacology (Berl), 2005, 181(4), 741-750.
[9] Ola M Ghoneim, et al. Bioorg Med Chem . 2006 Oct 1;14(19):6640-58.

Synonyms

1-Propanamine, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-, hydrochloride (1:1)

5H-Dibenzo[a,d]cycloheptene-Δ^5,γ-propylamine, 10,11-dihydro-N,N-dimethyl-, hydrochloride

1-Propanamine, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-, hydrochloride

Amitriptyline hydrochloride

10,11-Dihydro-N,N-dimethyl-5H-dibenzo[a,d]cycloheptene-Δ⁵,γ-propylamine hydrochloride

5-(3-Dimethylaminopropylidene)dibenzo[a,d][1,4]cycloheptadiene hydrochloride

Tryptizol

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NIH 10794

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Amineurin

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Triptizol

Domical

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Amilent

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Amiprin

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Pinsaun

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Anapsique

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Redomex

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Pinsanu

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Tryptanol

Lantron

Amyzol

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Euplit

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ADT

[3-(10,11-Dihydro-dibenzo[a,d]cyclohepten-5-ylidene)-propyl]-dimethyl-amine; hydrochloride