[CAS NO. 128-53-0] N-Ethylmaleimide (NEM)

Name: N-Ethylmaleimide (NEM)
Brand: Arctom Scientific
SKU: SLK-S3692

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PRODUCTS SPECIFICATIONS [128-53-0]

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Catalog

SLK-S3692

Brand

Selleck

CAS

128-53-0

DESCRIPTION [128-53-0]

Overview

MDL	MFCD00005509
Molecular Weight	125.13
Molecular Formula	C6H7NO2
SMILES	C(C)N1C(=O)C=CC1=O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It is an irreversible inhibitor of all , with alkylation occurring at the active site thiol group. N-Ethylmaleimide (NEM) inactivates endogenous . N-Ethylmaleimide (NEM) specifically inhibits phosphate transport in mitochondria.

In vitro

N-Ethylmaleimide inactivates endogenous deubiquitinating enzymes (DUBs) and specifically inhibits phosphate transport in mitochondria.

References

[1] Wang B, et al. Cell Rep. 2022 Mar 22;38(12):110538.
[2] Matsuda H, et al. Life Sci. 1999;65(2):PL27-32.

Synonyms

1H-Pyrrole-2,5-dione, 1-ethyl-

Maleimide, N-ethyl-

1-Ethyl-1H-pyrrole-2,5-dione

N-Ethylmaleimide

NEM

Ethylmaleimide

Maleic acid N-ethylimide

NSC 7638

1-Ethyl-2,5-dihydro-1H-pyrrole-2,5-dione