[CAS NO. 1377049-84-7] Velpatasvir

Name: Velpatasvir
Brand: Arctom Scientific
SKU: SLK-S3724

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PRODUCTS SPECIFICATIONS [1377049-84-7]

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Catalog

SLK-S3724

Brand

Selleck

CAS

1377049-84-7

DESCRIPTION [1377049-84-7]

Overview

MDL	MFCD28411371
Molecular Weight	883.00
Molecular Formula	C49H54N8O8
SMILES	C([C@@H](NC(OC)=O)C(C)C)(=O)N1[C@](C=2NC=3C4=C(C=C5C(=C4)OCC=6C5=CC=C(C6)C=7NC(=NC7)[C@]8(N(C([C@H](NC(OC)=O)C9=CC=CC=C9)=O)C[C@@H](COC)C8)[H])C=CC3N2)(CC[C@@H]1C)[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.1325 mL	5.6625 mL	11.3250 mL
5 mM	0.2265 mL	1.1325 mL	2.2650 mL
10 mM	0.1133 mL	0.5663 mL	1.1325 mL
50 mM	0.0227 mL	0.1133 mL	0.2265 mL

Description

Velpatasvir (GS-5816,VEL) is a second-generation inhibitor that inhibits hepatitis C viral replication through acting on the crucial "membranous web" that facilitates RNA replication.

Targets

NS5A ^[1]

In vitro

Velpatasvir (VEL, GS-5816) is a novel pan-genotypic hepatitis C virus (HCV) nonstructural protein 5A (NS5A) inhibitor with activity against genotype 1 (GT1) to GT6 HCV replicons. It is a selective inhibitor of HCV RNA replication with mean 50% effective concentrations (EC50s) against GT1 to GT6 of 6 to 130 pM.

References

[1] Mir F, et al. Drug Des Devel Ther. 2017, 11:497-502.

Synonyms

Carbamic acid, N-[(1R)-2-[(2S,4S)-2-[5-[1,11-dihydro-2-[(2S,5S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-5-methyl-2-pyrrolidinyl][2]benzopyrano[4′,3′:6,7]naphth[1,2-d]imidazol-9-yl]-1H-imidazol-2-yl]-4-(methoxymethyl)-1-pyrrolidinyl]-2-oxo-1-phenylethyl]-, methyl ester

Velpatasvir

GS 5816

Methyl [(2S)-1-[(2S,5S)-2-[9-[2-[(2S,4S)-1-[(2R)-2-[(methoxycarbonyl)amino]-2-phenylacetyl]-4-(methoxymethyl)pyrrolidin-2-yl]-1H-imidazol-5-yl]-1,11-dihydroisochromeno[4′,3′:6,7]naphtho[1,2-d]imidazol-2-yl]-5-methylpyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate