[CAS NO. 82854-37-3] Echinacoside

Name: Echinacoside
Brand: Arctom Scientific
SKU: SLK-S3783

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PRODUCTS SPECIFICATIONS [82854-37-3]

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Catalog

SLK-S3783

Brand

Selleck

CAS

82854-37-3

DESCRIPTION [82854-37-3]

Overview

MDL	MFCD00075695
Molecular Weight	786.73
Molecular Formula	C35H46O20
SMILES	O(C(C=CC1=CC(O)=C(O)C=C1)=O)[C@H]2[C@H](O[C@H]3[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O3)[C@@H](O)[C@H](OCCC4=CC(O)=C(O)C=C4)O[C@@H]2CO[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.2711 mL	6.3554 mL	12.7108 mL
5 mM	0.2542 mL	1.2711 mL	2.5422 mL
10 mM	0.1271 mL	0.6355 mL	1.2711 mL
50 mM	0.0254 mL	0.1271 mL	0.2542 mL

Description

Echinacoside, a natural polyphenolic compound, has various biological activities, such as antioxidative, anti-inflammatory, neuroprotective, hepatoprotective, nitric oxide radical-scavenging and vasodilative actions. Echinacoside, one of the phenylethanoids isolated from the stems of Cistanche salsa, elicits neuroprotection by activating Trk receptors and their downstream signal pathways. Echinacoside also has a remarkable antiosteoporotic activity.

In vitro

Echinacoside behaves in vitro as an anti-oxidant and a potent free radical scavenger. It has been shown to rescue SH-SY5Y neuronal cells from TNF-alpha-induced apoptosis. Echinacoside significantly attenuates glutamate-induced neurotoxicity and exhibits neuroprotective activities in vitro. Echinacoside has significant neuroprotective effects on TNFα-induced apoptosis in SHSY5Y neuronal cells by maintaining mitochondrial function, decreasing the generation of reactive oxygen species, increasing the expression of the antiapoptotic protein Bcl-2 and inhibiting caspase-3 activity through an antioxidation mechanism.

In vivo

Echinacoside has neuroprotective effects in the mouse MPTP model of Parkinson's disease. Treatment with echinacoside improves motor behavior and attenuated the depletion of striatal dopamine, DOPAC and HVA in MPTP-lesioned mice.

References

[1] Geng X, et al. Eur J Pharmacol. 2007, 564(1-3):66-74.
[2] Deng M, et al. Eur J Pharmacol. 2004, 505(1-3):11-8.

Synonyms

β-D-Glucopyranoside, 2-(3,4-dihydroxyphenyl)ethyl O-6-deoxy-α-L-mannopyranosyl-(1→3)-O-[β-D-glucopyranosyl-(1→6)]-, 4-[3-(3,4-dihydroxyphenyl)-2-propenoate]

Echinacoside