[CAS NO. 14113-05-4] Royal jelly acid

Name: Royal jelly acid
Brand: Arctom Scientific
SKU: SLK-S3827

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PRODUCTS SPECIFICATIONS [14113-05-4]

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Catalog

SLK-S3827

Brand

Selleck

CAS

14113-05-4

DESCRIPTION [14113-05-4]

Overview

MDL	MFCD00204506
Molecular Weight	186.25
Molecular Formula	C10H18O3
SMILES	C(CCCCCO)C/C=C/C(O)=O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	5.3691 mL	26.8456 mL	53.6913 mL
5 mM	1.0738 mL	5.3691 mL	10.7383 mL
10 mM	0.5369 mL	2.6846 mL	5.3691 mL
50 mM	0.1074 mL	0.5369 mL	1.0738 mL

Description

Royal jelly acid (10-Hydroxy-trans-2-decenoic acid, 10H2DA) is the principal lipid component in royal jelly which is the food for queen and larvae honeybees. It is involved in several treatment processes of autoimmune and inflammatory diseases, including inhibition of lipopolysaccharide (LPS)- and interferon (IFN)-γ-stimulated macrophage responses, inhibition of T-cell proliferation and anti-rheumatoid activity.

In vitro

Royal jelly acid (10H2DA) is a unique fatty acid found specifically in royal jelly and shows various pharmacological activities. With respect to inhibition of innate immune signals, however, 10H2DA shows a quite restricted effect which is dependent upon the stimulation.

In vivo

The Royal jelly acid (10H2DA) concentration that can inhibit innate immune signals is more than a few millimolars, but reaching the effective concentration when administering to the gastrointestinal tract or skin is relatively easy.

References

[1] Sugiyama T, et al. Endocr Metab Immune Disord Drug Targets. 2012, 12(4):368-76.

Synonyms

2-Decenoic acid, 10-hydroxy-, (2E)-

2-Decenoic acid, 10-hydroxy-, (E)-

Royal jelly acid

2-Decenoic acid, 10-hydroxy-, trans-

(2E)-10-Hydroxy-2-decenoic acid

10-Hydroxy-trans-2-decenoic acid

trans-10-Hydroxy-2-decenoic acid

(E)-10-Hydroxy-2-decenoic acid

10-Hydroxy-2E-decenoic acid

NSC 87516

Biosil