[CAS NO. 84687-43-4] Astragaloside IV

Name: Astragaloside IV
Brand: Arctom Scientific
SKU: SLK-S3901

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PRODUCTS SPECIFICATIONS [84687-43-4]

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Catalog

SLK-S3901

Brand

Selleck

CAS

84687-43-4

DESCRIPTION [84687-43-4]

Overview

MDL	-
Molecular Weight	784.97
Molecular Formula	C41H68O14
SMILES	C[C@]12[C@]3([C@]4([C@]5(C4)[C@@]([C@@H](O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)C3)(C(C)(C)[C@@H](O[C@H]7[C@H](O)[C@@H](O)[C@H](O)CO7)CC5)[H])CC[C@]1(C)[C@]([C@@H](O)C2)([C@]8(C)O[C@H]([C@@](C)(C)O)CC8)[H])[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.2739 mL	6.3697 mL	12.7393 mL
5 mM	0.2548 mL	1.2739 mL	2.5479 mL
10 mM	0.1274 mL	0.6370 mL	1.2739 mL
50 mM	0.0255 mL	0.1274 mL	0.2548 mL

Description

Astragaloside IV (AST-IV, AS-IV) is a bioactive saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine. It has various effect on the cardiovascular, immune, digestive, and nervous systems. AS-IV suppresses activation of p-, p-, p- and p-.

Targets

JNK ^[2]

ERK ^[2]

Akt ^[2]

mTOR ^[2]

NF-κB ^[2]

In vitro

Astragaloside IV probably alleviates leptin resistance by comprehensive modulation of ObR/STAT3 signaling transduction in neuronal cells.

In vivo

Administration of astragaloside IV (AS-IV) reduces albuminuria, ameliorates changes in the glomerular and tubular pathology, and decreases urinary NAG, NGAL, and TGF-β1 in db/db mice. AS-IV also attenuates the diabetes-related activation of Akt/mTOR, NFκB, and Erk1/2 signaling pathways without causing any detectable hepatotoxicity. AS-IV lowers blood glucose levels in streptozotocin (STZ)-induced diabetic models. It prevents body weight gain and reduced accumulation of fat tissues in HFD fed mice. Astragaloside IV actively participates in the modulation of energy homeostasis.

References

[1] Huili Sun, et al. Sci Rep. 2016, 6: 32545.
[2] Hui Wu, et al. Sci Rep. 2016, 6: 30190.

Synonyms

β-D-Glucopyranoside, (3β,6α,16β,20R,24S)-20,24-epoxy-16,25-dihydroxy-3-(β-D-xylopyranosyloxy)-9,19-cyclolanostan-6-yl

1H,19H-Cyclopropa[9,10]cyclopenta[a]phenanthrene, β-D-glucopyranoside deriv.

9,19-Cyclolanostane, β-D-glucopyranoside deriv.

(3β,6α,16β,20R,24S)-20,24-Epoxy-16,25-dihydroxy-3-(β-D-xylopyranosyloxy)-9,19-cyclolanostan-6-yl β-D-glucopyranoside

Astragaloside IV

Astrasieversianin XIV

Cyclosiversioside F

Astraversianin XIV

Cyclosieversioside F