[CAS NO. 128-57-4] Sennoside B

Name: Sennoside B
Brand: Arctom Scientific
SKU: SLK-S4018

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PRODUCTS SPECIFICATIONS [128-57-4]

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Catalog

SLK-S4018

Brand

Selleck

CAS

128-57-4

DESCRIPTION [128-57-4]

Overview

MDL	MFCD00151528
Molecular Weight	862.74
Molecular Formula	C42H38O20
SMILES	O=C1C=2C([C@@](C=3C1=C(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)C=CC3)([C@@]5(C=6C(C(=O)C=7C5=CC=CC7O[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)=C(O)C=C(C(O)=O)C6)[H])[H])=CC(C(O)=O)=CC2O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.1591 mL	5.7955 mL	11.5910 mL
5 mM	0.2318 mL	1.1591 mL	2.3182 mL
10 mM	0.1159 mL	0.5795 mL	1.1591 mL
50 mM	0.0232 mL	0.1159 mL	0.2318 mL

Description

Sennoside B, a kind of irritant laxative isolated from rhei rhizome, inhibits PDGF-stimulated cell proliferation., Sennoside B，一种从大黄根茎中分离得到的刺激性泻药，抑制PDGF刺激的细胞增殖。

Targets

PDGFR ^[1]

In vitro

Sennoside B, a kind of irritant laxative isolated from rhei rhizome, inhibits platelet-derived growth factor (PDGF)-stimulated MG63 cell proliferation by binding to PDGF-BB and its receptor and down-regulating the PDGFR-beta signaling pathway. Pre-incubation of PDGF-BB with sennoside B inhibits the phosphorylation of pathway components including Ak strain transforming protein (AKT), signal transducer and activator of transcription 5 (STAT-5) and extracellular signal-regulated kinase 1/2 (ERK1/2). It also inhibits bovine serum monoamine oxidase with IC50 of 9 μM.

In vivo

LD50: Mice 5000 mg/kg (i.g.); Rats 5000mg/kg (i.g.).

References

[1]?Hiraoka A, et al. Chem Pharm Bull, 1989, 37(10), 2744-2746.
[2] Chen YC, et al. Life Sci. 2009, 84(25-26), 915-922.
[3] Mengs U, et al. Pharmacology, 1988, 36(Suppl. 1), 180-187.

Synonyms

[9,9′-Bianthracene]-2,2′-dicarboxylic acid, 5,5′-bis(β-D-glucopyranosyloxy)-9,9′,10,10′-tetrahydro-4,4′-dihydroxy-10,10′-dioxo-, (9R,9′S)-

Sennoside B

[9,9′-Bianthracene]-2,2′-dicarboxylic acid, 5,5′-bis(β-D-glucopyranosyloxy)-9,9′,10,10′-tetrahydro-4,4′-dihydroxy-10,10′-dioxo-, (R*,S*)-

(9R,9′S)-5,5′-Bis(β-D-glucopyranosyloxy)-9,9′,10,10′-tetrahydro-4,4′-dihydroxy-10,10′-dioxo[9,9′-bianthracene]-2,2′-dicarboxylic acid