[CAS NO. 52-01-7] Spironolactone

Name: Spironolactone
Brand: Arctom Scientific
SKU: SLK-S4054

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PRODUCTS SPECIFICATIONS [52-01-7]

Store

Catalog

SLK-S4054

Brand

Selleck

CAS

52-01-7

DESCRIPTION [52-01-7]

Overview

MDL	-
Molecular Weight	416.57
Molecular Formula	C24H32O4S
SMILES	C[C@@]12[C@]3(CC[C@]1([C@]4([C@](CC2)([C@]5(C)C(C[C@H]4SC(C)=O)=CC(=O)CC5)[H])[H])[H])OC(=O)CC3

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.4006 mL	12.0028 mL	24.0056 mL
5 mM	0.4801 mL	2.4006 mL	4.8011 mL
10 mM	0.2401 mL	1.2003 mL	2.4006 mL
50 mM	0.0480 mL	0.2401 mL	0.4801 mL

Description

Spironolactone is a potent antagonist of the with of 77 nM.

Targets

Androgen Receptor ^[1]

77 nM

In vitro

Spironolactone is a strong AR antagonist (IC50 ~ 77 nM), a weak GR antagonist (IC50 ~ 2.4 μM), and a weak PR agonist (EC50 ~ 740 nM). Spironolactone inhibits androstanolone binding in rat prostate nuclei and androstanolone specific binding in rat prostate cytosol.

In vivo

Spironolactone (1 mg/day) exerts anti-androgenic activity in rats. A single pretreatment of spironolactone (1 mg/rat) inhibits specific and saturable uptake of hormone into prostate induced by tracer dose administration of [H]testosterone.

References

[1] Fagart J, et al. J Biol Chem, 2010, 285(39), 29932-29940.
[2] Bonne C, et al. Mol Cell Endocrinol, 1974, 2(1), 59-67.

Synonyms

Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, γ-lactone, (7α,17α)-

17α-Pregn-4-ene-21-carboxylic acid, 17-hydroxy-7α-mercapto-3-oxo-, γ-lactone, acetate

Spiro[17H-cyclopenta[a]phenanthrene-17,2′(5′H)-furan], pregn-4-ene-21-carboxylic acid deriv.

SC 9420

3-(3-keto-7α-Acetylthio-17β-hydroxy-4-androsten-17α-yl)propionic acid lactone

Aldactone

Aldactone A

17-Hydroxy-7α-mercapto-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactone 7-acetate

3-(3-Oxo-7α-acetylthio-17β-hydroxy-4-androsten-17α-yl)propionic acid-γ-lactone

Spironolactone

Spironolactone A

3′-(3-Oxo-7α-acetylthio-17β-hydroxyandrost-4-en-17α-yl)-propionic acid lactone

7α-Acetylthio-3-oxo-17α-pregn-4-ene-21,17β-carbolactone

Verospiron

7α-(Acetylthio)-17-hydroxy-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactone

Verospirone

Spiresis

Spiridon

Spirolang

Spirone

Uractone

Spirolactone

Duraspiron

Spiretic

Spiroderm

Altex

Urusonin

Osyrol

Dira

Supra-Puren

Almatol

Spiro-Tablinen

Aquareduct

Aldace

Sagisal

Xenalon

Aldopur

Laractone

Sincomen

Osiren

Suracton

Nefurofan

Lacalmin

Abbolactone

Lacdene

Spirolone

Diatensec

Deverol

Euteberol

Spiroctan

NSC 150399

Quimolactona

Berlactone

Novo-Spiroton

Spironol