[CAS NO. 13463-41-7] Zinc Pyrithione

Name: Zinc Pyrithione
Brand: Arctom Scientific
SKU: SLK-S4075

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PRODUCTS SPECIFICATIONS [13463-41-7]

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Catalog

SLK-S4075

Brand

Selleck

CAS

13463-41-7

DESCRIPTION [13463-41-7]

Overview

MDL	MFCD00067336
Molecular Weight	317.7
Molecular Formula	C10H8N2O2S2Zn
SMILES	[Zn+2]12([O-]N3C(=[S]1)C=CC=C3)[O-]N4C(=[S]2)C=CC=C4

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.1476 mL	15.7381 mL	31.4762 mL
5 mM	0.6295 mL	3.1476 mL	6.2952 mL
10 mM	0.3148 mL	1.5738 mL	3.1476 mL
50 mM	0.0630 mL	0.3148 mL	0.6295 mL

Description

Zinc pyrithione (OM-1563) is an antifungal and antibacterial agent disrupting membrane transport by blocking the .

Targets

Proton pump ^[1]

In vitro

Zinc pyrithione is considered as a coordination complex of zinc. The pyrithione ligands, which are formally monoanions, are chelated to Zn via oxygen and sulfur centers. In the crystalline state, zinc pyrithione exists as a centrosymmetric dimer, where each zinc is bonded to two sulfur and three oxygen centers. In solution, however, the dimers dissociate via scission of one Zn-O bond. Zinc pyrithione, which is a dimer but is probably biologically active as a monomer, induces plasma membrane depolarization with half-maximal effect (K) of about 0.3 mM. Zinc pyrithione is an unusual synthetic potentiator that potently activates both heterologous and native M channels by inducing channel opening at the resting potential.

In vivo

Zinc pyrithione rapidly accumulated in the tissues of the exposed mussels, proportionately to both exposure concentration and time. Even though the 7-d median lethal concentration (LC50) = 8.27 μM established here appears high with respect to reported ZnPT environmental concentrations, the results indicate that this biocide could represent a threat for marine organisms in coastal environments and that further investigations on its biological effects at sublethal doses are needed.

References

[1] Ermolayeva E, et al. Appl Environ Microbiol, 1995, 61(9), 3385-3390.
[2] Xiong Q, et al. Nat Chem Biol, 2007, 3(5), 287-296.
[3] Marcheselli M, et al. Environ Toxicol Chem, 2010, 29(11), 2583-2592.

Synonyms

Zinc, bis[1-(hydroxy-κO)-2(1H)-pyridinethionato-κS²]-, (T-4)-

Zinc, bis(1-hydroxy-2(1H)-pyridinethionato)-

Zinc, bis(1-hydroxy-2(1H)-pyridinethionato-O,S)-, (T-4)-

2(1H)-Pyridinethione, 1-hydroxy-, zinc complex

(T-4)-Bis[1-(hydroxy-κO)-2(1H)-pyridinethionato-κS²]zinc

Zinc pyrithione

Omadine Zinc

Pyrithione zinc

Bis(1-hydroxy-2-(1H)-pyridinethionato)zinc

Zinc, bis(2-pyridinylthio)-, N,N′-dioxide

Zinc 2-pyridinethiol 1-oxide

Vancide P

Zinc Omadine

ZPT

OM 1563

2-Mercaptopyridine 1-oxide zinc salt

Zinc 1-hydroxy-2-pyridinethione

2-Pyridinethiol 1-oxide zinc salt

Zinc pyrethion

2-Pyridinethiol N-oxide zinc salt

Zincpolyanemine

Zinc 2-mercaptopyridine N-oxide

Zinc pyridine-2-thione-N-oxide

FSB 8332

1-Hydroxy-2-pyridinethione, zinc salt

Evafine P 50

Tomicide Z 50

Bis(1-hydroxy-2(1H)-pyridinethionato)zinc

Hokucide ZPT

Finecide ZPT

Biocut ZP

Bis(2-pyridinethiol 1-oxide)zinc

BC-J

Tomicide ZPT 50

Niccanon SKT

Niccanon ZP

Marukacide YP-DP

Zinc bis(2-pyridylthio-1-oxide)

Sebulon Shampoo

Desquaman

Danex

ZNP Bar

Tomicide ZPT

NSC 290409

AF-Z

Tomicide ZPT 100

Zinc Pyrion

2-Pyridylthiol-1-oxide zinc salt

Microban Additive ZO 1

ZO-E

Zn Omadine ZOE

Microban Z 01

Sanitized TH 22-27

Clean-Bio ZP

Sanaizol 200

Dantrol

Zincopan

Sanitized TH 27-24BT

Slaoff 95

Slaoff 94

Vedexil-PZ

Hybricide 89

Denistat ANK

ZOE-T

Intercide ZNP

SR-A 103

ZnPT

Zinc Omadine ZOE Dispersion

Zinc Omadine ZOE

TH 22-27

Zinc bis(2-mercaptopyridine-N-oxide)

Zinc Omacide ZOE

FK-C

RUCO-BAC ZPY