[CAS NO. 144143-96-4] Eprosartan Mesylate

Name: Eprosartan Mesylate
Brand: Arctom Scientific
SKU: SLK-S4102

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PRODUCTS SPECIFICATIONS [144143-96-4]

Store

Catalog

SLK-S4102

Brand

Selleck

CAS

144143-96-4

DESCRIPTION [144143-96-4]

Overview

MDL	MFCD08141807
Molecular Weight	520.62
Molecular Formula	C23H24N2O4S.CH4O3S
SMILES	S(C)(=O)(=O)O.C(N1C(/C=C(\CC2=CC=CS2)/C(O)=O)=CN=C1CCCC)C3=CC=C(C(O)=O)C=C3

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.9208 mL	9.6039 mL	19.2079 mL
5 mM	0.3842 mL	1.9208 mL	3.8416 mL
10 mM	0.1921 mL	0.9604 mL	1.9208 mL
50 mM	0.0384 mL	0.1921 mL	0.3842 mL

Description

Eprosartan(SKF-108566J) is a nonpeptide angiotensin II receptor antagonist, [H]-eprosartan binds to the AT1 receptor with K of 0.83 nM in rat vascular smooth muscle cells.

Features

At least 1,000- to 10,000-fold more selective for the AT1 than the AT2 receptor.

Targets

AT1 receptor ^[1]

0.83 nM(Kd)

In vitro

Eprosartan inhibits [I]-angiotensin II binding with IC50 1.4 nM to 3.9 nM in human tissues (adrenal cortex, liver, cloned AT1 receptor) and 1.5 nM to 9.2 nM in rat tissues (e.g. mesenteric artery, adrenal cortex, renal glomerulus). Eprosartan (100 nM), but not an AT2 antagonist, completely blocks angiotensin II-induced isotonic fluid absorption in rabbit isolated perfused proximal convoluted tubules.

References

[1] Plosker GL, et al. Drugs, 2000, 60(1), 177-201.
[2] Ohlstein EH, et al. Pharmacology, 1997, 55(5), 244-251.

Synonyms

2-Thiophenepropanoic acid, α-[[2-butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-yl]methylene]-, (αE)-, methanesulfonate (1:1)

2-Thiophenepropanoic acid, α-[[2-butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-yl]methylene]-, (E)-, monomethanesulfonate

2-Thiophenepropanoic acid, α-[[2-butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-yl]methylene]-, (αE)-, monomethanesulfonate

SKF 108566J

Eprosartan mesylate

Eprosartan methanesulfonate